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Dr. Clyne's Vascular Kinetics Laboratory conducts research at the interface of engineering, biochemistry, and vascular biology. In their prior work, the group largely focused on how an altered glucose environment (e.g., in diabetes) impaired endothelial cell response to shear stress and cyclic strain. Dr. Clyne and her lab have demonstrated that endothelial cells in high glucose do not respond appropriately to mechanical stimuli. Today, the group focuses primarily on the opposite question: how the mechanical environment affects endothelial cell glucose metabolism. They are integrating mechanobiology and metabolism, with the hope of using metabolic engineering to decrease the burden of cardiovascular disease and cancer. With new collaboration opportunities at the University of Maryland, Dr. Clyne and her lab group plan to extend their cell and animal work into human studies.

• Laminar and disturbed flow effects on endothelial glucose metabolism
• Computational models of endothelial glucose metabolism
• Impaired endothelial mechanosensing in pulmonary arterial hypertension
• Arterial stiffness in spinal cord injury
• Perfusion effects on cancer metabolism
• Vascular glucose transport in traumatic brain injury and Alzheimer’s disease
• Pressure myography-on-a-chip
• Energy Fields to Control Mitochondrial Metabolism

Publications on Google Scholar