Event
BIOE Seminar Series: Matthew Reilly
Friday, December 2, 2016
9:00 a.m.-10:00 a.m.
Pepco Room (1105), Jeong H. Kim Engineering Building
Dr. Silvina Matysiak
matysiak@umd.edu
Matthew Reilly
Department of Biomedical Engineering
Department of Ophthalmology & Visual Science
The Ohio State University
Big Ten Exchange Program Seminar:
Bio-chemo-mechanics of Presbyopia and Ocular Trauma
Presbyopia is the most common vision disorder, resulting in compromised near vision for nearly all individuals over the age of 50. The mechanism(s) by which the eye becomes presbyopic remain poorly understood, though most indications point to natural aging processes in the lens, including growth, remodeling, and stiffening. These changes, which occur in parallel, result in an altered balance of residual stresses between the lens and its capsule in the accommodated state. However, their respective contributions to presbyopia are as yet unknown. Our lab is currently combining biochemical/biomechanical experiments, mechanobiological experiments, and multi-scale modeling for elucidating which of these factors is most important with a long-term goal of reversing or preventing these changes.
Ocular trauma is increasingly common in both military and civilian sectors, is the most common vision-related cause of hospitalization, and the fourth-most common type of battlefield injury. The increased use of improvised explosive devices (IEDs) is thought to be the main contributing factor to military eye injuries and may indicate that the eye is particularly susceptible to blast. We have developed experimental and computational models of blast injury to the eye to understand the mechanical injury mechanisms, offer improved diagnosis, and suggest preventative measures. Most recently, we developed a novel animal model for traumatic optic neuropathy which will be used to develop diagnostic criteria and test candidate treatments for this vision-threatening condition.
About the Speaker
Matthew Reilly completed a BS in 2003 and MS in 2004 in chemical and materials engineering at the University of Dayton before earning a PhD in chemical engineering at Washington University in 2008. He then completed post-doctoral training in biomechanics and ophthalmology at the Washington University School of Medicine, St. Louis VA Medical Center, and University of Oxford until 2011 when he joined the Department of Biomedical Engineering at the University of Texas in San Antonio. Most recently, he joined the Department of Biomedical Engineering and Department of Ophthalmology and Visual Science at OSU in January 2016.
