Special Bioengineering Seminar: Giuliano Scarcelli

Monday, February 10, 2014
9:00 a.m.-10:00 a.m.
Pepco Room (1105), Jeong H. Kim Engineering Building
Professor Adam Hsieh
hsieh@umd.edu

Biomechanical Imaging with Brillouin Microscopy
Giuliano Scarcelli

Harvard Medical School and Wellman Center for Photomedicine
Massachusetts General Hospital

In the past years, we have developed a biomedical imaging technology based on Brillouin light scattering to measure the biomechanical properties of biological tissue and biomaterials. Spontaneous Brillouin scattering arises from the interaction of light and acoustic phonons that are inherently present in a sample. Upon this interaction, part of the scattered light acquires a GHz frequency shift directly related to the longitudinal elastic modulus of the sample. Thus, by detecting this small spectral shift, the sample’s elastic properties can be measured without physical contact. We will discuss the development of the high-throughput spectrometer that enabled transforming Brillouin technology from point-sample spectroscopy requiring high laser power to an imaging modality that can be safely applied in vivo. The first area of biomedical applications we have explored is in ophthalmology where Brillouin imaging can measure changes in corneal and lens elasticity by aging, by progression of disease or in response to treatment/drugs. This has resulted in an on-going clinical trial to test the potential of Brillouin technology as diagnostic and therapy-monitoring tool for corneal ectasia. We will conclude the seminar by discussing our current efforts to develop high-resolution Brillouin confocal microscopy for cell biomechanics.

Audience: Graduate  Faculty  Post-Docs 

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