Assistant Professor Adam Hsieh
Lab Director, Orthopaedic Mechanobiology Lab
Ph.D., University of California, San Diego, 2000
Room 3242 Jeong H. Kim Engineering Building
E-mail: hsieh@umd.edu
Phone: (301) 405-7397
Fax: (301) 314-6868
Research Interests
Orthopaedic biomechanics; soft tissue mechanobiology; mechanisms of intervertebral disc degeneration; mechanobiologic strategies for developing spatially-complex tissue engineered constructs.
Recent Publications
Doro CJ, Forward DP, Kim H, Nascone JW, Sciadini MF, Hsieh AH, Osgood G, O’Toole RV. "Does 2.5 cm of symphyseal widening differentiate anteroposterior compression I from anteroposterior compression II pelvic ring injuries?" J Orthop Trauma, in press.
Rastogi A, Thakore P, Leung A, Benavides M, Machado MC, Morschauser MA, Hsieh AH. "Environmental regulation of notochordal gene expression in nucleus pulposus cells." J Cell Physiol, in press.
Floyd JCP, O’Toole RV, Forward DP, Stall A, Nabili M, Shillingburg D, Hsieh AH, Nascone JW. "A biomechanical comparison of proximal locking plates and blade plates for the treatment of comminuted subtrochanteric femur fractures." J Orthop Trauma, in press.
Hsieh AH, Hwang D, Ryan DA, Freeman A, Kim H. "Degenerative changes induced by intervertebral disc puncture are associated with sufficiency of biomechanical function." Spine 34: 998-1005, 2009.
Haudenschild AK, Hsieh AH, Kapila S, Lotz JC. "Pressure and distortion regulate human mesenchymal stem cell gene expression." Ann Biomed Eng 37: 492-502, 2009.
Nesson S, Yu M, Zhang XM, and Hsieh AH. "Miniature fiber-optic pressure sensor with composite polymer-metal diaphragm for intradiscal pressure measurements." J Biomed Optics 13: 0440401-0440408, 2008.
Lotz JC, Hadi T, Bratton C, Reiser KM, Hsieh AH. "Anulus fibrosus tension inhibits degenerative structural changes in lamellar collagen." Eur Spine J 17: 1149-1159, 2008.
Hsieh AH, Wagner DR, Cheng LY, Lotz JC. "Dependence of mechanical behavior of the murine tail disc on regional material properties - a parametric finite element study." ASME J Biomech Eng 127(7): 1158-1167, 2005.
McKean JM, Hsieh AH, Sung KL. "Epidermal growth factor differentially affects integrin-mediated adhesion and proliferation of ACL and MCL fibroblasts." Biorheology 41: 139-152, 2004.
Hsieh AH, Lotz JC. "Prolonged spinal loading induces matrix metalloproteinase-2 activation in intervertebral discs." Spine 28: 1781-1788, 2003.
Lotz JC, Hsieh AH, Walsh AL, Palmer EI, Chin JR. "Mechanobiology of the intervertebral disc." Biochem Soc Trans 30: 853-858, 2002.
Hsieh AH, Sah RL, Paul Sung KL. "Biomechanical regulation of type I collagen gene expression in ACLs in organ culture." J Orthop Res 20: 325-331, 2002.
Hsieh AH, Tsai CM, Ma QJ, Lin T, Banes AJ, Villarreal FJ, Akeson WH, Sung KL. "Time-dependent increases in type-III collagen gene expression in medical collateral ligament fibroblasts under cyclic strains." J Orthop Res 18: 220-227, 2000.
Scientific and Professional Memberships
Organizer, 12th Annual Computational Methods in Orthopaedic Biomechanics (Pre-ORS), 2004.
Honors and Awards
NIH Ruth L. Kirchstein National Research Service Award, 2001.
