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Muro, Silvia

Silvia Muro
Associate Professor
5143 Plant Sciences Building
Email: 
Phone: 
301-405-4777
Fax: 
301-314-9075
Lab Description

News About This Professor

 

Research Interests 

Mechanisms of endocytic vesicular transport: their role in physiology and disease, and their translational application for the controlled delivery of nano-scale therapeutics to precise targets at the sub-cellular level (targeting, intracellular drug delivery, endocytosis, cell culture, animal models, pharmacokinetics, microscope imaging).

Education 

Ph.D., Universidad Autonoma de Madrid (Spain), 1999

Honors and Awards 

  • A. James Clark School of Engineering Junior Faculty Outstanding Research Award
  • Outstanding Invention of the Year, Life Sciences, University of Maryland, College Park, Md. (2011) (Silvia Muro)
  • Outstanding paper, American Society of Nanomedicine (2011) (Rasa Ghaffarian)
  • Outstanding paper, Controlled Release Society (2011) (Tridib Bhowmick)
  • Outstanding paper, AIChE Mid-America (2010) (Laura Northrop)
  • Outstanding paper, Nanomedicine and Drug Delivery Symposium (2011 and 2007) (Daniel Serrano and Carmen Garncho, respectively)
  • Outstanding paper, Spanish Society for Inborn Errors of Metabolism, Spain (2005) (Silvia Muro)
  • Outstanding paper, Society for the Study of Inborn Errors of Metabolism, UK. (2000) (Silvia Muro)
  • Ramón Areces Foundation Postdoctoral Fellowship, Spain (2000-2002) (Silvia Muro)
  • NATO International Postdoctoral Fellowship (2000) (Silvia Muro)
  • Scientist Development, American Heart Association (2004-2008) (Silvia Muro)
  • Howard Hughes Medical Institute Undergraduate Research Fellowship (2012 and 2010) (Rasa Ghaffarian and Maria Ansar, respectively)
  • National Science Foundation Graduate Research Fellowship Program (2010-2013) & (2011-2014) (Daniel Serrano and Rasa Ghaffarian & Rachel Manthe, respectively)

Professional Memberships 

  • American Heart Association
  • American Society for Cell Biology
  • BioMedical Engineering Society
  • Controlled Release Society

Books and Chapters 

Hsu J, Muro S. (2011) Nanomedicine and drug delivery strategies for treatment of genetic diseases. In: Plaseska-Karanfilska D, ed. Genetic Disease. InTech, Rijeka, Croatia. Chapter 14:241-266.

Muro S.* (2007) ICAM-1 and VCAM-1. In: Aird, W., editor. Endothelial Biomedicine. Cambridge University Press. New York, NY. Chapter 117:1058-1070.
 

Selected Publications 

* denotes senior corresponding author

Papademetriou, I. T., Garnacho C., Schuchman E. H., & Muro S. (2013). In vivo performance of polymer nanocarriers dually-targeted to epitopes of the same or different receptors. Biomaterials. 34(13), 3459-66.

Han, J., Zern B. J., Shuvaev V. V., Davies P. F., Muro S., & Muzykantov V. (2012). Acute and Chronic Shear Stress Differently Regulate Endothelial Internalization of Nanocarriers Targeted to Platelet-Endothelial Cell Adhesion Molecule-1. ACS Nano.

Papademetriou, J., Garnacho C., Serrano D., Bhowmick T., Schuchman E. H., & Muro S. (2012). Comparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptor. J Inherit Metab Dis.

Bacalocostantis, I., Mane V. P., Kang M. S., Goodley A. S., Muro S., & Kofinas P. (2012). Effect of thiol pendant conjugates on plasmid DNA binding, release, and stability of polymeric delivery vectors. Biomacromolecules.13(5), 1331-9.

Muro, S. (2012).  Challenges in design and characterization of ligand-targeted drug delivery systems. J Control Release.

Ghaffarian, R., Bhowmick T., & Muro S. (2012). Transport of nanocarriers across gastrointestinal epithelial cells by a new transcellular route induced by targeting ICAM-1. J Control Release.

Simone, E. A., Zern B. J., Chacko A-M., Mikitsh J. L., Blankemeyer E. R., Muro S., et al. (2012).  Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124. Biomaterials. 33(21), 5406-13.

Serrano D, Bhowmick T, Chadha R, Garnacho C, Muro S. (2012) Intercellular adhesion molecule 1 engagement modulates sphingomyelinase and ceramide, supporting uptake of drug carriers by the vascular endothelium. Arterioscler Thromb Vasc Biol. 32(5):1178-85. Highlighted in the editorial.

Mane, V., & Muro S. (2012).  Biodistribution and endocytosis of ICAM-1-targeting antibodies versus nanocarriers in the gastrointestinal tract in mice. Int J Nanomedicine. 7, 4223-37.

Garnacho C, Serrano D, Muro S. (2012) A fibrinogen-derived peptide provides ICAM-1-specific vascular targeting and intra-endothelial transport of polymers nanocarriers in cell cultures and mice. J Pharm Exp Ther, 340(3):638-647.

Hsu, J., Northrup L., Bhowmick T., & Muro S. (2011). Enhanced delivery of α-glucosidase for Pompe disease by ICAM-1-targeted nanocarriers: comparative performance of a strategy for three distinct lysosomal storage disorders. Nanomedicine.

Bhowmick T, Berk E, Cui X, Muzykantov V*, Muro S. (2012) Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1. J Control Rel, 157(3):485-492.

Calderon, A.J., Bhowmick T., Leferovich J., Burman B., Pichette B., Muzykantov V., et al. (2011). Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. Journal of Controlled Release. 150(1), 37-44.

Hsu, J., Serrano D., Bhowmick T., Kumar K., Shen Y., Kuo Y C., Muro S. (2011).  Enhanced endothelial delivery and biochemical effects of α-galactosidase by ICAM-1-targeted nanocarriers for Fabry disease. Journal of Controlled Release. 149(3), 323-31. Highlighted on the cover and in the editorial.

Shuvaev, V. V., Ilies M. A., Simone E., Zaitsev S., Kim Y., Cai S., et al. (2011).  Endothelial Targeting of Antibody-Decorated Polymeric Filomicelles. ACS Nano.

Calderon A, Bhowmick T, Leferovich J, Burmann B, Pichette B, Muzykantov V, Eckmann D*, Muro S. (2011) Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. J Control Rel, 150(1):37-44.

Muro, S. (2010). New biotechnological and nanomedicine strategies for treatment of lysosomal storage disorders. Wiley interdisciplinary reviews. Nanomedicine and Nanobiotechnology. 2(2), 189-204.

Calderon, A.J., Muzykantov V., Muro S., & Eckmann D.M. (2009). Flow dynamics, binding and detachment of spherical carriers targeted to ICAM-1 on endothelial cells. Biorheology. 46(4), 323-41.

Garnacho, C., Albelda S. M., Muzykantov V. R., & Muro S. (2008).  Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes. Journal of Controlled Release.130(3), 226-33.

Garnacho, C., Dhami R., Simone E., Dziubla T., Leferovich J., Schuchman E. H., et al. (2008).  Delivery of acid sphingomyelinase in normal and niemann-pick disease mice using intercellular adhesion molecule-1-targeted polymer nanocarriers. The Journal of Pharmacology and Experimental Therapeutics. 325(2), 400-8.

Garnacho, C., Shuvaev V., Thomas A., McKenna L., Sun J., Koval M., et al. (2008).  RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1. Blood. 111(6), 3024-33.

Rossin, R., Muro S., Welch M. J., Muzykantov V. R., & Schuster D. P. (2008).  In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium. Journal of Nuclear Medicine. 49(1), 103-11.

Finikova, O. S., Lebedev A. Y., Aprelev A., Troxler T., Gao F., Garnacho C., et al. (2008).  Oxygen microscopy by two-photon-excited phosphorescence. Chemphyschem. 9(12), 1673-9.

Muro, S.*, Garnacho C., Champion J. A., Leferovich J., Gajewski C., Schuchman E. H., et al. (2008).  Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. Molecular Therapy. 16(8), 1450-8.

Selected Presentations 

"Sub-cellular transport of drug delivery systems: an intricate road." Muro S. Annual Meeting of the Controlled Release Society. Quebec City, QC, Canada, July 2012.

"Targeted drug delivery systems: achievements and challenges." Muro S. International conference of Nanotechnology and Nanomedicine. Philadelphia, Pa., August 2012. (Invited)

"ICAM-1 targeting of nanocarriers to the central nervous system." Muro S. International Brains for Brain Workshop. Waterville Valley, N.H., August 2012. (Invited)

"Transport of enzymes coupled to ICAM-1-targeted nanocarriers across gastrointestinal epithelial cells." Muro S. World Organization for Research on Rare Disorders. San Diego, Ca., February 2012.

"Delivery of lysosomal enzyme replacement therapies by targeted nanocarriers." Muro S. International Nanomedicine and Drug Delivery Symposium. Salt Lake City, Utah, October 2012. (Invited)

"Targeting therapeutic carriers across the blood-brain barrier." Muro S. Annual Meeting of the Controlled Release Society. National Harbor, Baltimore, Md., July 2011.

"Optimizing intracellular delivery of drug carriers by targeting receptors of vesicular transport." Meng M., Garnacho C., and Muro S. BioMedical Engineering Society, St Louis, Mo., October 2008.

"Control of subcellular delivery of targeted polymer therapeutics by endothelial vesicular transport." Muro S. International Symposium on Polymer Therapeutics. Valencia, Spain, May 2008.

"In vivo intracellular delivery of ICAM-1-targeted nanocarriers for enzyme replacement therapies of lysosomal disorders." Garnacho C., Dhami R., Schuchman E., Muzykantov V., Muro S. Conference on Controlled Drug Delivery. Pamplona, Spain, October 2006.

"Nanocarriers targeted to clathrin-independent pathways for lysosomal enzyme replacement therapy." Muro S., Dhami R., Muzykantov V., Schuchman E. Society for Inborn Errors of Metabolism. Palma de Mallorca, Spain, October 2005.

"Immunotargeting to ICAM-1 provides binding, internalization and lysosomal delivery of acid sphingomyelinase." Muro S., Schuchman E., Muzykantov V. American Society of Human Genetics. Toronto, ON, Canada, October 2004.

Related News 

Muro, IBBR Faculty Awarded Maryland Innovation Initiative Grants
UMD's Institute for Bioscience & Biotechnology Research awarded two $115,000 grants. June 5, 2017

Manthe, Tang Receive Dean's Awards
BIOE graduate students recognized for outstanding research. June 2, 2017

BIOE Capstone 2017: Projects Focus on Pediatric Care, Physical Therapy, Pulmonary Tumors, and More
BIOE hosted it's largest-ever Capstone Design competition on May 10th, 2017. May 17, 2017

Dr. Silvia Muro, Genisphere Partner to Advance Drug Delivery Systems
Genisphere LLC, University of Maryland sign collaborative research agreement through BIOE's Dr. Sivlia Muro. April 26, 2017

University of Maryland to Lead NIH-Funded Center for Engineering Complex Tissues
UMD to Collaborate with Rice University, Wake Forest to Advance 3-D Printing Applications for Regenerative Medicine April 10, 2017

Working to Improve Oral Drug Delivery
BIOE associate professor looks to control transport of therapeutics through physiological barriers. April 1, 2017

Muro Develops Technique to Improve Oral Drug Delivery Using Targeted Nanocarriers
Associate Professor Silvia Muro (Joint, IBBR) and fellow UMD researchers are working to improve oral drug delivery to targets by protecting against the effects of gastric conditions. October 31, 2016

UMD Researchers Explore New Avenues in Treatment of Lysosomal Storage Diseases
Associate Professor Silvia Muro's lab examines treatment options for rare metabolic disorders. January 5, 2015

Chip Used to Separate Bacteria from Food Samples Wins Professor Venture Fair
BioE Assistant Professor Javier Atencia Named Professor Venture Fair Winner December 3, 2014

Behrens, Manthe Join Future Faculty Program
Program prepares graduate students for careers in academia. January 16, 2014

3D-Printed Heart Implant Wins Professor Venture Fair
Polymer grafts can be custom-fitted, promote tissue growth. November 21, 2013

ResearchFest 2013
ResearchFest 2013 September 22, 2013

4 BioE Grad Students Win UMD Distinguished TA Awards
Ferlin, Ganesan, Lin and Manthe recognized by Center for Teaching Excellence. May 22, 2013

Clark Professors Honored as Top Women Professors in Maryland
Professors Espy-Wilson and Muro recognized by StateStats.org for excellence in and out of the classroom May 7, 2013

2012-2013 BioE Undergraduate Awards
Exceptional students recognized at annual ceremony. April 9, 2013

UMD and JHU Students Join Forces for Research Day
"Amplifying the Field" celebrates undergraduate contributions to biomedical research. March 13, 2013

Rappaport Wins HHMI Fellowship
Award supports senior’s efforts to develop treatments for rare genetic disorders. January 24, 2013

Kofinas, Muro Honored for Research
Clark School Outstanding Research Awards recognize professors' influential and ground-breaking work. December 14, 2012

Drug Delivery System Wins Professor Venture Fair
Muro, Ghaffarian honored at UMD Bioscience Research Day. December 11, 2012

Chen's Biomedical Imaging Featured in American Center for Physics Art Exhibit
From Here to Infinity examines art inspired and created by science and technology. December 5, 2012

Ghaffarian Nanocarrier Paper on Cover of Journal of Controlled Release
Work presents gastrointestinal transcellular drug delivery route. October 10, 2012

Hsu Wins BioE Outstanding Graduate Research Award
Student recognized for work on drug-delivery system for the treatment of rare diseases. October 5, 2012

Muro Group: Understanding Drug Delivery Via Natural Cell Pathway
New results bring successful targeted drug delivery from bloodstream to tissues one step closer. June 29, 2012

Muro Promoted
Faculty member becomes Associate Professor, receives tenure. May 30, 2012

Award Supports Development of Safer Batteries for Biomedical Devices
Sophomore Mian Khalid wins prestigious Howard Hughes Medical Institute fellowship for work with Kofinas Group. April 27, 2012

ResearchFest 2012
Marquardt receives top prize; Chiang, Fernandes and Hsu also selected for honors. April 12, 2012

Muro Group Member Wins HHMI Fellowship
CMNS undergraduate Maria Ansar receives award for proposal on drug delivery mechanisms. February 22, 2012

Muro Group: New Collaboration on Treatment of Neurodegenerative Disorders
NIH funding will support work on transporting new drugs across the blood-brain barrier. February 22, 2012

Hsu Presents Work on Rare Lysosomal Disorder
Graduate student wins WORLD travel scholarship, attends conference as invited speaker. February 22, 2012

Ghaffarian Wins Nanomedicine Poster Award
Grad student recognized for work on drug nanocarriers that cross the gastrointestinal epithelial barrier. November 17, 2011

Serrano Wins Nanomedicine Poster Award
Muro Group member recognized for work on drug delivery. November 14, 2011

Jordan Makes Research an Integral Part of her Curriculum
BioE senior works with ARL, Gemstone, Muro Group and more. November 9, 2011

Bhowmick Wins CRS Outstanding Consumer & Diversified Products Paper Award
Polymer nanocarriers cross blood-brain barrier. August 8, 2011

Record Year for NSF Fellowships
8 current and former BioE students receive awards, honorable mentions. April 20, 2011

Taking Aim at a Rare Lysosomal Storage Disease
Muro Group seeks to improve enzyme replacement therapy for Fabry disease with new nanocarriers. April 19, 2011

Hsu Drug Delivery Research Wins GRID Poster Session
Grad student "pushes the boundaries of science" with work on moving drugs across the blood brain barrier. April 17, 2011

Novel Drug Delivery: Life Sciences Invention of the Year
Muro, Ghaffarian's targeted oral delivery system takes top honors. April 14, 2011

Capstone 2010: Devices for Diagnostics, Improved Treatments, and Personal Health
See projects from tomorrow's innovators. May 18, 2010

Muro Wins $1.72M National Institutes of Health R01 Grant
Group to develop new treatments for genetic diseases affecting lungs, brain. April 9, 2010

Hsu Wins Best Poster Award for Research on Rare Neuromuscular Disorder
Targeted drug delivery prototype for Pompe disease wins Nanoscience/Nanotechnology division at annual event. December 1, 2009

BioE Welcomes 3 New Faculty Members
Balaras, Muro and White arrive for Fall '08. August 27, 2008