Mechanisms of endocytic vesicular transport: their role in physiology and disease, and their translational application for the controlled delivery of nano-scale therapeutics to precise targets at the sub-cellular level (targeting, intracellular drug delivery, endocytosis, cell culture, animal models, pharmacokinetics, microscope imaging).
Ph.D., Universidad Autonoma de Madrid (Spain), 1999
Honors and Awards
- A. James Clark School of Engineering Junior Faculty Outstanding Research Award
- Outstanding Invention of the Year, Life Sciences, University of Maryland, College Park, Md. (2011) (Silvia Muro)
- Outstanding paper, American Society of Nanomedicine (2011) (Rasa Ghaffarian)
- Outstanding paper, Controlled Release Society (2011) (Tridib Bhowmick)
- Outstanding paper, AIChE Mid-America (2010) (Laura Northrop)
- Outstanding paper, Nanomedicine and Drug Delivery Symposium (2011 and 2007) (Daniel Serrano and Carmen Garncho, respectively)
- Outstanding paper, Spanish Society for Inborn Errors of Metabolism, Spain (2005) (Silvia Muro)
- Outstanding paper, Society for the Study of Inborn Errors of Metabolism, UK. (2000) (Silvia Muro)
- Ramón Areces Foundation Postdoctoral Fellowship, Spain (2000-2002) (Silvia Muro)
- NATO International Postdoctoral Fellowship (2000) (Silvia Muro)
- Scientist Development, American Heart Association (2004-2008) (Silvia Muro)
- Howard Hughes Medical Institute Undergraduate Research Fellowship (2012 and 2010) (Rasa Ghaffarian and Maria Ansar, respectively)
- National Science Foundation Graduate Research Fellowship Program (2010-2013) & (2011-2014) (Daniel Serrano and Rasa Ghaffarian & Rachel Manthe, respectively)
- American Heart Association
- American Society for Cell Biology
- BioMedical Engineering Society
- Controlled Release Society
Books and Chapters
Hsu J, Muro S. (2011) Nanomedicine and drug delivery strategies for treatment of genetic diseases. In: Plaseska-Karanfilska D, ed. Genetic Disease. InTech, Rijeka, Croatia. Chapter 14:241-266.
Muro S.* (2007) ICAM-1 and VCAM-1. In: Aird, W., editor. Endothelial Biomedicine. Cambridge University Press. New York, NY. Chapter 117:1058-1070.
* denotes senior corresponding author
Papademetriou, I. T., Garnacho C., Schuchman E. H., & Muro S. (2013). In vivo performance of polymer nanocarriers dually-targeted to epitopes of the same or different receptors. Biomaterials. 34(13), 3459-66.
Han, J., Zern B. J., Shuvaev V. V., Davies P. F., Muro S., & Muzykantov V. (2012). Acute and Chronic Shear Stress Differently Regulate Endothelial Internalization of Nanocarriers Targeted to Platelet-Endothelial Cell Adhesion Molecule-1. ACS Nano.
Papademetriou, J., Garnacho C., Serrano D., Bhowmick T., Schuchman E. H., & Muro S. (2012). Comparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptor. J Inherit Metab Dis.
Bacalocostantis, I., Mane V. P., Kang M. S., Goodley A. S., Muro S., & Kofinas P. (2012). Effect of thiol pendant conjugates on plasmid DNA binding, release, and stability of polymeric delivery vectors. Biomacromolecules.13(5), 1331-9.
Muro, S. (2012). Challenges in design and characterization of ligand-targeted drug delivery systems. J Control Release.
Ghaffarian, R., Bhowmick T., & Muro S. (2012). Transport of nanocarriers across gastrointestinal epithelial cells by a new transcellular route induced by targeting ICAM-1. J Control Release.
Simone, E. A., Zern B. J., Chacko A-M., Mikitsh J. L., Blankemeyer E. R., Muro S., et al. (2012). Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124. Biomaterials. 33(21), 5406-13.
Serrano D, Bhowmick T, Chadha R, Garnacho C, Muro S. (2012) Intercellular adhesion molecule 1 engagement modulates sphingomyelinase and ceramide, supporting uptake of drug carriers by the vascular endothelium. Arterioscler Thromb Vasc Biol. 32(5):1178-85. Highlighted in the editorial.
Mane, V., & Muro S. (2012). Biodistribution and endocytosis of ICAM-1-targeting antibodies versus nanocarriers in the gastrointestinal tract in mice. Int J Nanomedicine. 7, 4223-37.
Garnacho C, Serrano D, Muro S. (2012) A fibrinogen-derived peptide provides ICAM-1-specific vascular targeting and intra-endothelial transport of polymers nanocarriers in cell cultures and mice. J Pharm Exp Ther, 340(3):638-647.
Hsu, J., Northrup L., Bhowmick T., & Muro S. (2011). Enhanced delivery of α-glucosidase for Pompe disease by ICAM-1-targeted nanocarriers: comparative performance of a strategy for three distinct lysosomal storage disorders. Nanomedicine.
Bhowmick T, Berk E, Cui X, Muzykantov V*, Muro S. (2012) Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1. J Control Rel, 157(3):485-492.
Calderon, A.J., Bhowmick T., Leferovich J., Burman B., Pichette B., Muzykantov V., et al. (2011). Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. Journal of Controlled Release. 150(1), 37-44.
Hsu, J., Serrano D., Bhowmick T., Kumar K., Shen Y., Kuo Y C., Muro S. (2011). Enhanced endothelial delivery and biochemical effects of α-galactosidase by ICAM-1-targeted nanocarriers for Fabry disease. Journal of Controlled Release. 149(3), 323-31. Highlighted on the cover and in the editorial.
Shuvaev, V. V., Ilies M. A., Simone E., Zaitsev S., Kim Y., Cai S., et al. (2011). Endothelial Targeting of Antibody-Decorated Polymeric Filomicelles. ACS Nano.
Calderon A, Bhowmick T, Leferovich J, Burmann B, Pichette B, Muzykantov V, Eckmann D*, Muro S. (2011) Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. J Control Rel, 150(1):37-44.
Muro, S. (2010). New biotechnological and nanomedicine strategies for treatment of lysosomal storage disorders. Wiley interdisciplinary reviews. Nanomedicine and Nanobiotechnology. 2(2), 189-204.
Calderon, A.J., Muzykantov V., Muro S., & Eckmann D.M. (2009). Flow dynamics, binding and detachment of spherical carriers targeted to ICAM-1 on endothelial cells. Biorheology. 46(4), 323-41.
Garnacho, C., Albelda S. M., Muzykantov V. R., & Muro S. (2008). Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes. Journal of Controlled Release.130(3), 226-33.
Garnacho, C., Dhami R., Simone E., Dziubla T., Leferovich J., Schuchman E. H., et al. (2008). Delivery of acid sphingomyelinase in normal and niemann-pick disease mice using intercellular adhesion molecule-1-targeted polymer nanocarriers. The Journal of Pharmacology and Experimental Therapeutics. 325(2), 400-8.
Garnacho, C., Shuvaev V., Thomas A., McKenna L., Sun J., Koval M., et al. (2008). RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1. Blood. 111(6), 3024-33.
Rossin, R., Muro S., Welch M. J., Muzykantov V. R., & Schuster D. P. (2008). In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium. Journal of Nuclear Medicine. 49(1), 103-11.
Finikova, O. S., Lebedev A. Y., Aprelev A., Troxler T., Gao F., Garnacho C., et al. (2008). Oxygen microscopy by two-photon-excited phosphorescence. Chemphyschem. 9(12), 1673-9.
Muro, S.*, Garnacho C., Champion J. A., Leferovich J., Gajewski C., Schuchman E. H., et al. (2008). Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. Molecular Therapy. 16(8), 1450-8.
"Sub-cellular transport of drug delivery systems: an intricate road." Muro S. Annual Meeting of the Controlled Release Society. Quebec City, QC, Canada, July 2012.
"Targeted drug delivery systems: achievements and challenges." Muro S. International conference of Nanotechnology and Nanomedicine. Philadelphia, Pa., August 2012. (Invited)
"ICAM-1 targeting of nanocarriers to the central nervous system." Muro S. International Brains for Brain Workshop. Waterville Valley, N.H., August 2012. (Invited)
"Transport of enzymes coupled to ICAM-1-targeted nanocarriers across gastrointestinal epithelial cells." Muro S. World Organization for Research on Rare Disorders. San Diego, Ca., February 2012.
"Delivery of lysosomal enzyme replacement therapies by targeted nanocarriers." Muro S. International Nanomedicine and Drug Delivery Symposium. Salt Lake City, Utah, October 2012. (Invited)
"Targeting therapeutic carriers across the blood-brain barrier." Muro S. Annual Meeting of the Controlled Release Society. National Harbor, Baltimore, Md., July 2011.
"Optimizing intracellular delivery of drug carriers by targeting receptors of vesicular transport." Meng M., Garnacho C., and Muro S. BioMedical Engineering Society, St Louis, Mo., October 2008.
"Control of subcellular delivery of targeted polymer therapeutics by endothelial vesicular transport." Muro S. International Symposium on Polymer Therapeutics. Valencia, Spain, May 2008.
"In vivo intracellular delivery of ICAM-1-targeted nanocarriers for enzyme replacement therapies of lysosomal disorders." Garnacho C., Dhami R., Schuchman E., Muzykantov V., Muro S. Conference on Controlled Drug Delivery. Pamplona, Spain, October 2006.
"Nanocarriers targeted to clathrin-independent pathways for lysosomal enzyme replacement therapy." Muro S., Dhami R., Muzykantov V., Schuchman E. Society for Inborn Errors of Metabolism. Palma de Mallorca, Spain, October 2005.
"Immunotargeting to ICAM-1 provides binding, internalization and lysosomal delivery of acid sphingomyelinase." Muro S., Schuchman E., Muzykantov V. American Society of Human Genetics. Toronto, ON, Canada, October 2004.