Event
BIOE Seminar: Lori Setton
Friday, September 27, 2019
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2132
Emily Rosenthal
301 405 3936
erosent1@umd.edu
Dr. Lori Setton
Lucy and Stanley Lapota Distinguished Professor and Chair of Biomedical Engineering
Washington University in St. Louis
Challenges and Strategies for Intra-articular Delivery of Drugs in the Treatment of Arthritis
Research and development have advanced clinical use of protein and small molecule drugs that can modify the progression and symptoms of osteoarthritis and inflammatory pain, including mediators of TNF-alpha and the NF-kappa B pathway. Systemic administration of these drugs can have serious side effects that motivate use of local drug delivery strategies, such as intra-articular injection, to prolong drug residence time and decrease serum exposure. Dr. Setton's laboratory is dedicated to developing classes of in situ forming drug depots that will re-solubilize and delivery drug over time. This talk will review the synthesis and design of intra-articular drug depots, and show evidence that drugs retain substantial bioactivity and disease-modifying effects in vivo. Ex vivo models are built to advance an understanding of factors affecting drug transport in the joint space towards the goal to design optimal drug delivery strategies.
About the Speaker
Dr. Setton received her B.S.E. from Princeton University in Mechanical and Aerospace Engineering, with M.S. and Ph.D. degrees in Mechanical Engineering from Columbia University. Dr. Setton joined the Department of Biomedical Engineering at Duke University in 1994, where she served as the Bevan Distinguished Professor of Biomedical Engineering and Orthopaedic Surgery. In 2015, Dr. Setton joined the Department of Biomedical Engineering at Washington University and holds the position of Lopata Distinguished Professor & Chair of Biomedical Engineering.
Dr. Setton’s research focuses on understanding the mechanisms for degeneration and regeneration of soft tissues of the musculoskeletal system. Recent work focuses on development of in situ forming hydrogels for drug delivery and tissue regeneration in the knee joints and spine. She has funded her lab through grants from the NIH, NSF, Whitaker Foundation, Coulter Foundation, OREF, AO Foundation, and research agreements with several corporations.
Dr. Setton has over 180 publications and developed technology for licensing to commercial partners. Dr. Setton has served as a permanent member of NIH and NSF study sections, as a consultant to NIH and AAOS, and on the Boards of the Biomedical Engineering Society, Orthopaedic Research Society and World Council on Biomechanics. She completed a term as President of the Biomedical Engineering Society in 2018 and is a Fellow of the BMES, ASME, AIMBE and has received a PECASE Award, Dean's Award for Outstanding Research, Graduate Dean's Award for Excellence in Mentoring, and ASME’s Mow Medal.
