Event
CANCELED - BIOE Seminar: Dr. Biju Parakkedan
Friday, May 1, 2020
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2132
Emily Rosenthal
301 405 3936
erosent1@umd.edu
Dr. Biju Parekkadan
Associate Professor, Biomedical Engineering
Associate Professor, Surgery
Rutgers University
Cell Therapy meets Drug Delivery
Cellular therapy is enabling new approaches to tackle significant unmet needs in areas such as regenerative medicine and immunotherapy. The pharmacology of cell therapeutics becomes of critical importance to assure that these new drugs work reproducibly and effectively. Cell pharmacology can benefit from adapting principles of classical molecular drug pharmacokinetics (PK) and pharmacodynamics (PD) to quantitatively understand rate-limiting constraints of cell fate after administration. Future innovations focused on improvements in drug delivery using a PK/PD perspective can aid in designing a cell therapeutic product to overcome any pharmacological barriers for a given disease application. Herein, we present a perspective on the development of an ex vivo mesenchymal stromal therapeutic using a PK/PD framework and also present examples of general cell engineering techniques that implicitly influence the PK/PD curve by genetically modifying cells to regulate their in vivo duration, biodistribution, and activity.
About the Speaker
Dr. Parekkadan is an Associate Professor of Biomedical Engineering with a laboratory that specializes in cell and genetic engineering. He has experience in developing biotech products as a founder of Sentien, a clinical stage pioneer of ex vivo cell therapeutics, as well as advising several companies as a founding member of CellOne Partners. Dr. Parekkadan received his PhD in Chemical and Medical Engineering from the Harvard-MIT Division of Health Sciences and Technology, where he also completed all MD studies. His efforts have been recognized through notable awards including being named Young Mentor of the Year by Harvard Medical School and a Presidential Early Career Scientist from the Office of the White House, the highest honor of an early stage investigator.
