CANCELED: ChBE Seminar Series: Sensitive Electronic Devices for Multi-Scale Biological Measurements
Speaker: Arvind Balijepalli, Mechanical Engineer, Physical Measurement Lab
National Istitute of Standards and Technology (NIST)
Title: Sensitive Electronic Devices for Multi-Scale Biological Measurements
The detection and characterization of biomolecules at low copy number in multi-component solutions has the potential to unlock numerous applications in personalized healthcare from diagnostics to drug discovery. However, such measurements remain challenging to realize with existing techniques due to constraints associated with sensitivity and cost. I will discuss ongoing work that seeks to realize chip-based measurements of biomarkers and biomolecule interactions at spatial scales ranging from cells to single molecules. In particular, I will present our work that employs label-free electronic biomarker measurements within small ensembles and up to the single-molecule limit. A key focus of our work is to develop technologies that are sensitive, selective, rapid, and portable to allow cost-effective measurements at the point of care.
Dr. Arvind Balijepalli is a Mechanical Engineer in the Physical Measurement Laboratory at the National Institute of Standards and Technology (NIST). He received his Ph.D. at the University of Maryland, College Park in 2011. After completing a joint National Research Council postdoctoral fellowship between NIST and the National Institutes of Health, he joined NIST in 2014. At NIST, he develops new chip-scale sensing techniques to enable measurements of fundamental biophysical phenomenon at multiple scales ranging from biomolecular interactions to dynamics in cell and tissue mimics.