Event
BIOE Seminar Series: Ashutosh Chilkoti (Duke)
Friday, April 27, 2018
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2132
Dr. Steven Jay
smjay@umd.edu
Dr. Ashutosh Chilkoti
Alan L. Kaganov Professor of Biomedical Engineering,
Chair, Department of Biomedical Engineering
Duke University
Translating Molecular Bioengineering from the Lab to the Patient
This talk will highlight recent work from my laboratory that illustrates the clinical translation of molecular bioengineering technologies for point-of-care clinical diagnostics and drug delivery. In the first example, I will discuss a point-of-care diagnostic —the D4 assay — that we have developed, in which all reagents are printed and stored on a “non-fouling”—protein and cell resistant—polymer brush. The D4 assay has a speed and sensitivity that is as good or better than commercially available point-of-care tests and is far simpler, cheaper more rugged, and does not require a cold-chain. In the area of drug delivery, I will highlight two technologies: (1) an injectable delivery system based on thermally sensitive polypeptides for the sustained and tunable release of peptide drugs from a subcutaneous injection site that we have developed for treatment of type 2 diabetes; and (2) attachment-triggered self-assembly of recombinant peptide polymers that packages small molecules into soluble polymer nanoparticles that can improve the efficacy of many cancer chemotherapeutics.
