Our group aims to develop integrated microsystems that enable new applications not possible before. Using a systems approach, we are applying fundamentals of physics, chemistry, and engineering to solve problems relevant to today’s critical biomedical applications. In particular, we emphasize the use of amplification strategies to add orders of magnitude improvement to chemical and biomolecular sensing, while at the same time improving the simplicity and usability of the technology. Contact Dr. White or take a look at our most recent publications.
Each year our lab hosts one intern from JFK high school. The students experience the excitement of the daily problem-solving challenges that are an inherent part of a career in engineering, and they achieve a sense of accomplishment through their work in our lab.
Trulee utilized MATLAB to develop software tools for data analysis in the lab.
Bernard worked with microcontrollers to develop new instrumentation for the lab.
Justin investigated protocol variations in the synthesis of silver nanoparticles and the effect of these variations on surface enhanced Ramans spectroscopy.
Cataysha studied the chemical functionalization of cellulose paper for biosensing applications.
Emilio assisted Dr. White's lab by developing and testing material for the dual-credit engineering math course. In particular, Emilio worked with calculator-controlled robots that can assist with the teaching of mathematical principles.
During her internship, Rhitu was tasked with attempting a number of different synthesis technics for gold and silver nanoparticles. She is currently studying chemistry at Barnard College in New York, NY, and is on her way to becoming a first-generation college graduate.
Dr. White assisted the College of Education (Prof. Leigh Abts) and the Department of Defense (Jennifer Wolk, U.S. Navy, course instructor) to offer a dual-credit class to high school students that teaches mathematics for future engineering students through a hands-on approach. The class aimed to attract more students into top-tier engineering programs and to provide these students with the necessary skills to survive the challenges of the undergraduate engineering curriculum.
(August 24, 2016) Adam Berger has been named a Philip Merrill Presidential Scholar in recognition of his academic excellence.
(August 10, 2016) Adam Berger has received the BMES Undergraduate Design and Research Award for his work on therapeutic drug monitoring with paper SERS devices. The award will be presented at the 2016 BMES conference.
(April 25, 2016) Megan Dang has been awarded the SEEDS undergraduate research fellowship from summer 2016 and the 2016-2017 academic year.
(April 22, 2016) Kenya Colvin has been awarded the ASPIRE undergraduate research fellowship to continue her research in summer 2016.
(April 7, 2016) Adam Berger has been awarded the Dinah Berman Memorial Award for his combined academic excellence and service to the Clark School.
(April 7, 2016) Adam Berger has been awarded the Fischell Department of Bioengineering Outstanding Junior Award.
(April 6, 2016) Adam Berger has won a UMD HHMI summer research fellowship!
(March 31, 2016) Adam Berger is named a national Goldwater Scholar.
(February 4, 2016) John Goertz passed his Ph.D. proposal! Congratulations!
(August 6, 2015) Stephen Restaino passed his Ph.D. proposal! Congratulations!
(July 9, 2015) Adriel Sumathipala is selected as a regional finalist in the Google Science Fair.
(May 21, 2015) Kunal Pandit successfully defended his Ph.D. dissertation! Congratulations!
(March 31, 2015) Hieu Nguyen has been awarded the prestigious NSF Fellowship! Congratulations!
(March 13, 2015) Imaly Nanayakkara (Bioengineering Ph.D. student) and Hieu Nguyen (Bioengineering Ph.D. student) have joined our group.
(February 18, 2015) Our lab wins a MIPS award supported by the state of Maryland and Diagnostic anSERS.
(June 5, 2014) Kristen Giles passes her Bioengineering Undergraduate Honors thesis defense.
(May 14, 2014) Stephen Restaino wins the Distinguished Graduate Student Teaching Award from the University of Maryland Center for Teaching Excellence.
(March 10, 2014) Kristen Giles wins Best Undergraduate Research Poster Award at the Mid-Atlantic Micro/Nano Alliance annual symposium.
(January 1, 2014) John Goertz, the 2013 winner of the Fischell Fellowship, has joined the group.
Eric Hoppmann successfully defended his Ph.D. dissertation. Congratulations!
Soroush Yazdi successfully defended his Ph.D. dissertation. Congratulations!
Veemoon Yu was awarded the Fischell BIOE Outstanding Graduate Researcher for 2012-2013.
Kristen Giles has been accepted into the BIOE Honors Program.
Veemoon Yu successfully defended his Ph.D. dissertation. Congratulations!
Hoppmann wins GRID competition with presentation on paper-SERS detection of PCR products.
Virgile, Diagnostic anSERS, take third at the national Cupid's Cup Competition.
Our lab wins a MIPS award, supported by the state of Maryland and Diagnostic anSERS.
Yu's paper on inkjet-printed paper SERS dipsticks, swabs, and lateral flow concentration is selected for Analyst outside front cover.
Hoppmann, Virgile win Dingman Pitch Competition.
Katayoon Saadin successfully defended her Ph.D. dissertation. Congratulations! She is the first graduate from our research group.
Hoppmann, Virgile reach finals of MTECH's $75K Business Plan Competition.
Our group wins a collaboration award from the FDA Center of Excellence in Regulatory Science and Innovation.
Our paper-based SERS devices were featured by SPIE Newsroom.
Yazdi's optofluidic SERS paper selected for the Virtual Journal of Nanoscale Science and Technology and the Virtual Journal of Biological Physics Research.
Our group wins a Blue Ocean Grant from Ocean Optics.
Sean Virgile, the 2010 winner of the Fischell Fellowship, has joined the group.
C&EN reports on Yu's ink-jet-printed SERS array.
Yu publishes first ever ink-jet-printed SERS microdevice.
Currently we do not have any post-doc positions available.
In the Fischell Department of Bioengineering, graduate students do not select research groups until the end of their first year. Therefore, if you are interested in joining our group, please first apply for admission to the department.
Currently we do not have any undergraduate research positions available.
Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035
Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006
Kunal R. Pandit, Paul E. Rueger, Richard V. Calabrese, Srinivasa R. Raghavan, and Ian M. White, Assessment of surfactants for efficient droplet PCR in mineral oil using the pendant drop technique, Journal of Colloids and Surfaces B: Biointerfaces, 126, 489-495, 2015. DOI:10.1016/j.colsurfb.2015.01.001
Jeffrey M. Burke, Kunal Pandit, John P. Goertz, and Ian M. White, Fabrication of rigid microstructures with thiol-ene-based soft lithography for continuous-flow cell lysis, Biomicrofluidics, 8, 056503, 2014. DOI:10.1063/1.4897135.
Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Multiplex detection of DNA targets using polymerase chain reaction (PCR) and paper surface enhanced Raman spectroscopy (SERS) chromatography, Applied Spectroscopy, 68, 909-915, 2014. DOI:10.1366/14-07451.
Jeffrey M. Burke, Rebecca E. Zubajlo, Elisabeth Smela, and Ian M. White, High-throughput particle separation and concentration using spiral inertial filtration, Biomicrofluidics, 8, 024105 2014. DOI:10.1063/1.4870399.
Jordan F. Betz, Wei W. Yu, Yi Cheng, Ian M. White, and Gary W. Rubloff, Simple SERS substrates: powerful, portable, and full of potential, Physical Chemistry Chemical Physics, 16, 2224-2239, 2014. DOI:10.1039/C3CP53560F.
Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Inkjet-printed fluidic paper devices for chemical and biological analytics using surface enhanced Raman spectroscopy, Journal of Selected Topics in Quantum Electronics, 20, 7300510, 2014. DOI:10.1109/JSTQE.2013.2286076.
Soroush H. Yazdi, Kristen L. Giles, and Ian M. White, Multiplexed detection of DNA sequences using a competitive displacement assay in an microfluidic SERRS-based device, Analytical Chemistry, 85, 10605-10611, 2013. DOI:10.1021/ac402744z.
Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Highly sensitive and flexible inkjet printed SERS sensors on paper, Methods, 63, 219-224, 2013. DOI:10.1016/j.ymeth.2013.07.010.
Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, 138, 3679-3686 2013. DOI:10.1039/C3AN00673E.
Katayoon Saadin, Jeffrey M. Burke, Neerav P. Patel, Rebecca E. Zubajlo, and Ian M. White, Enrichment of tumor-initiating breast cancer cells within a mammosphere-culture microdevice, Biomedical Microdevices, 15, 645-655, 2013. DOI:10.1007/s10544-013-9755-y.
Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)
Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, in press, DOI:10.1039/C2AN36232E.
Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.
Soroush H. Yazdi and Ian M. White, An Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Chemical Contaminants, Analytical Chemistry, 84, 7992-7998, 2012. DOI:10.1021/ac301747b.
Katayoon Saadin and Ian M. White, Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications, Expert Reviews of Molecular Diagnostics, 13, 49-60, 2013. DOI:10.1586/erm.12.117.
Ian M. White, Soroush H. Yazdi, and Wei W. Yu, Optofluidic SERS: synergizing photonics and microfluidics for chemical and biological analysis, Microfluidics and Nanofluidics, 12, 205-216, 2012. DOI:10.1007/s10404-012-0962-2
Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.
Soroush H. Yazdi and Ian M. White, A nanoporous optofluidic microsystem for highly sensitive and repeatable SERS detection, Biomicrofluidics, 6, 014105, 2012. DOI:10.1063/1.3677369. (selected for publication in the Virtual Journal of Nanoscale Science and Technology and the Virtual Journal of Biological Physics Research)
Xudong Fan and Ian M. White, Optofluidic microsystems for chemical and biological analysis, Nature Photonics, 5, 591-597, 2011. DOI:10.1038/nphoton.2011.206.
I-Jane Chen and Ian M. White, High-sensitivity electrochemical enzyme-linked assay on a microfluidic interdigitated microelectrode, Biosensors and Bioelectronics, 26, 4375-4381, 2011. DOI:10.1016/j.bios.2011.04.044.
Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.
Jikun Liu, Ian M. White, and Don L. DeVoe, Nanoparticle-Functionalized Porous Polymer Monolith Detection Elements for Surface-Enhanced Raman Scattering, Analytical Chemistry, 83, 2119-2124, 2011. DOI:10.1021/ac102932d.
Ian M. White, Sample processing and sensing, Optical Biosensors Incubator: Future of Optical Biosensors for Point-of-Care Applications, Washington, D.C., 2015.
Ian M. White, Inkjet-printed fluidic paper SERS devices for chemical and biological analytics, Advances in Optics for Biotechnology, Medicine, and Surgery XIV, Vail, CO, 2015.
Ian M. White, SERS-based chemical and biological analytics on inkjet-fabricated paper devices, AVS Mid-Atlantic, Gaithersburg, MD, 2015.
Stephen M. Restaino and Ian M. White, Inkjet-fabricated surface enhanced Raman spectroscopy (SERS) sensors on paper for biosensing, Photonics West, 2015, San Francisco, CA.
John P. Goertz and Ian M. White, Smartphone-enabled filterless fluorescence assay utilizing the pyrene excimer, Photonics West, 2015, San Francisco, CA.
Ian M. White, Wei W. Yu, Eric P. Hoppmann, Soroush H. Yazdi, SERS-based biological analytics on inkjet-fabricated paper devices, SciX 2014, Reno, NV (Invited presentation).
Ian M. White, Sample preparation for point-of-care bloodstream infection diagnostics, Next Generation Diagnostics Summit 2014, Washington D.C. (Invited presentation).
Ian M. White, Surface enhanced Raman spectroscopy sensing of chemical and biological molecules on low-cost microporous devices, Complex Fluids II, 2014, Durham, NC (Invited presentation).
Wei W. Yu, Eric P. Hoppmann, and Ian M. White, Inkjet-printed fluidic paper SERS devices for chemical and biological analytics, SciX 2013, Milwaukee, WI (Invited presentation).
Ian M. White, Fluidic paper SERS devices for chemical and biological analytics, 2nd European Optical Society Conference on Optofluidics, 2013, Munich, Germany (Invited presentation).
Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, SPIE Defense, Security, and Sensing, 2013, Baltimore, MD.
Wei W. Yu and Ian M. White, Paper SERS chromatography for detection of trace analytes in complex samples, SPIE Defense, Security, and Sensing, 2013, Baltimore, MD.
Eric P. Hoppmann and Ian M. White, A paper-based inkjet-fabricated substrate for SERS detection and differentiation of PCR products, SPIE Defense, Security, and Sensing, 2013, Baltimore, MD.
Wei W. Yu and Ian M. White, Inkjet-Fabricated SERS-Active Swab-Dipstick, OSA Optical Sensors, 2012, Monterey, CA.
Soroush H. Yazdi and Ian M. White, A Nanoporous Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Melamine, CLEO, 2012, San Jose, CA
Wei W. Yu and Ian M. White, Optofluidic SERS on Paper: A Lateral Flow Concentration Assay Using Inkjet Fabricated SERS-Active Substrates, CLEO, 2012, San Jose, CA
Ian M. White and Wei W. Yu, Optofluidic SERS on inkjet-fabricated paper-based substrates (Invited presentation), Photonics West, 2012, San Francisco, CA
Katayoon Saadin and Ian M. White, Mammosphere culture of cancer stem cells in a microfluidic device, Photonics West, 2012, San Francisco, CA
Soroush H. Yazdi and Ian M. White, 3D nanoporous optofluidic device for high sensitivity SERS detection, Photonics West, 2012, San Francisco, CA
Ian M. White and Katayoon Saadin, Studying the mechanisms of cancer metastasis in microsystems, Lab on a Chip World Congress, 2011, South San Francisco, CA
Ian M. White, Optofluidic biosensors, APC Workshop: Biomedical Optical Sensors - Differentiators for Winning Technologies, 2011, Toronto, ON.
Ian M. White, Ink-Jet-Printed Optofluidic SERS for Molecular Analysis (Invited presentation), OSA Optical Sensors, 2011, Toronto, ON.
Wei W. Yu and Ian M. White, Paper-based optofluidic SERS using ink-jet-printed substrates, Photonics West 2011, San Francisco, CA.
Katayoon Saadin and Ian M. White, A novel microfluidic device for on-chip enrichment of tumorigenic breast cancer cells via mammosphere culture, MRS Fall Meeting 2010, Boston, MA.
I-Jane Chen and Ian M. White, Sandwich Structure Electrochemical Assay for Single Stranded DNA Detection, IEEE Sensors 2010, Waikoloa, HI.
Kunqiang Jiang, Ian M. White, and Don L. DeVoe, Detection of trace explosives by SERS using 3-D nanochannel arrays, microTAS 2010, Groningen, The Netherlands
Jikun Liu, Ian M. White, and Don L. DeVoe, microTAS 2010, Groningen, The Netherlands
Jikun Liu, Don L. DeVoe, and Ian M. White, Microfluidic SERS Using a 3-Dimensional Porous Monolith as a SERS-Active Solid Phase in a Microchannel, CLEO 2010, San Jose, CA
I-Jane Chen and Ian M. White, Electrochemical Immunoassay for DNA Sensor, Pittcon 2010, Orlando, FL.
Eric Hoppmann and Ian M. White, Electrostatic Purification of Nucleic Acids for Micro Total Analysis Systems, Southern Biomedical Engineering Conference 2010, College Park, MD.
Farnoosh Farahi and Ian M. White, Integration of Capillary Ring Resonator Biosensor with PDMS Microfluidics for Label-free Biosensing, Southern Biomedical Engineering Conference 2010, College Park, MD.
Ian M. White, Optofluidic biosensing for the study of disease at the molecular level (Invited presentation), Photonics West 2010, San Francisco, CA.