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Our Research Group

A Multifaceted Approach

Our group aims to develop integrated microsystems that enable new applications not possible before. Using a systems approach, we are applying fundamentals of physics, chemistry, and engineering to solve problems relevant to today’s critical biomedical applications. In particular, we emphasize the use of amplification strategies to add orders of magnitude improvement to chemical and biomolecular sensing, while at the same time improving the simplicity and usability of the technology. Contact Dr. White or take a look at our most recent publications.

Projects

Inkjet-Printed SERS Substrates

Inkjet-Printed SERS Substrates

As a bio/chemical sensing technique, surface enhanced Raman spectroscopy (SERS) offers sensitivity comparable to that of fluorescence detection while providing highly specific information about the analyte. Although single molecule identification with SERS was demonstrated over a decade ago, today a need exists to develop practical solutions for point-of-sample and point-of-care SERS systems. We recently demonstrated the fabrication of SERS substrates by inkjet printing silver and gold nanostructures onto paper and other similar membranes, achieving detection limits comparable to conventional nanofabricated substrates. Furthermore, we have leveraged the fluidic properties of paper to enhance the performance of the SERS devices while also enabling unprecedented ease of use, which is critical for extending chemical and biological analytics from central labs out into the field. We are currently investigating the use of these paper-based SERS sensors for both chemical and biological sensing applications.

  • Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Multiplex detection of DNA targets using polymerase chain reaction (PCR) and paper surface enhanced Raman spectroscopy (SERS) chromatography, Applied Spectroscopy, 68, 909-915, 2014. DOI:10.1366/14-07451.

  • Jordan F. Betz, Wei W. Yu, Yi Cheng, Ian M. White, and Gary W. Rubloff, Simple SERS substrates: powerful, portable, and full of potential, Physical Chemistry Chemical Physics, 16, 2224-2239, 2014. DOI:10.1039/C3CP53560F.

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Inkjet-printed fluidic paper devices for chemical and biological analytics using surface enhanced Raman spectroscopy, Journal of Selected Topics in Quantum Electronics, 20, 7300510, 2014. DOI:10.1109/JSTQE.2013.2286076.

  • Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Highly sensitive and flexible inkjet printed SERS sensors on paper, Methods, 63, 219-224, 2013. DOI:10.1016/j.ymeth.2013.07.010.

  • Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, 138, 3679-3686 2013. DOI:10.1039/C3AN00673E.

  • Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)

  • Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.

  • Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.

PCR Sample Prep for the Point-of-Care

PCR Sample Prep for the Point-of-Care

We have invented a process that dramatically reduces the hands-on time and complexity of PCR sample preparation. This may be the key factor that finally enables PCR-based molecular diagnostics to be utilized in near-patient applications.

  • Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006

Catabolic Chain Reaction

Catabolic Chain Reaction

Publications in progress...

Functional Nucleic Acids for Biosensing

Functional Nucleic Acids for Biosensing

Publications in progress...

Rapid Phenotypic Detection of Antibiotic Resistance

Rapid Phenotypic Detection of Antibiotic Resistance

Publications in progress...

Next-Generation Rolling Circle Amplification

Next-Generation Rolling Circle Amplification

Publications in progress...

Therapeutic Drug Monitoring with SERS

Therapeutic Drug Monitoring with SERS

Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035

People

Our Lab

White Lab 2016

Our Principal Investigator

Dr. Ian White

Dr. Ian White

Associate Chair and Director of Undergraduate Studies
Fischell Department of Bioengineering
2216 Jeong H. Kim Engineering Bldg.
University of Maryland
College Park, MD 20742
301-405-6230


Joined the University of Maryland in 2008
Post-doc: University of Missouri, Life Sciences Center (2005–2008)
Ph.D. Electrical Engineering, Stanford University (2002)

Our Graduate Students

Stephen Restaino

Stephen Restaino

Joined White Lab in 2013
B.S. in Engineering Science and Mechanics, Virginia Tech (2011)
Previous Research:

  • De Vita Lab, Virginia Tech
    Tensile testing of soft tissue, including tendons and insect tracheal tubes
  • Shah Lab and Krauthamer Lab, Food and Drug Administration
    Biomechanical and functional effects of nerve implants

John Goertz

John Goertz

Fischell Fellow
Joined White Lab in 2014
B.S. in Physics and Cell & Molecular Biology, Seattle University (2013)
Previous Research:

  • Murphy Lab, Seattle University
    Atomic Force Microscopy analysis of protein interactions
  • Fontana Lab, Seattle University
    Thin-film investingations of the 2D Roshko formula

Imaly Nanayakkara

Imaly Nanayakkara

Joined White Lab in 2015
M.S. in Biomedical Engineering, Univerity of California - Irvine (2014)
B.S. in Biomedical Engineering, Boston University (2012)
Previous Research:

  • Lee Lab, UC Irvine
    Microfluidic protein microarrays using cavity acoustic transducers
  • Zaman Lab, Boston University
    Reagent storage on filter paper

Hieu Nguyen

Hieu Nguyen

NSF Fellow
Joined White Lab in 2015
B.A. in Biology, Brown University (2009)
Previous Research:

  • Stroud Lab, Miriam Hospital, Providence RI
    Biological bases of psychological stress response in adolescents
  • Shin Lab, University of Pennsylvania
    Roll of the innate immune system in the host-pathogen interactions of C. burnetii
  • Co-founder and Patent Analyst at Minds in Motion Electronics, LLC

Alessandra Zimmermann

Alessandra Zimmermann

Joined White Lab in 2015
B.S. in Chemistry with Biology minor, Carnegie Mellon (2013)
Previous Research:

  • Paukstelis Lab, University of Maryland
    DNA lattices for protein crystallography
  • Das Lab, Carnegie Mellon University
    3D structures utilizing click chemistry-modified RNA

Qian Zhang

Qian Zhang

Joined White Lab in 2015
Advised by Prof. Zhihong Nie
M.S. in Chemistry, Beijing University of Aeronautics and Astronautics
B.S. in Applied Chemistry, Beijing University of Aeronautics and Astronautics

Our Undergraduate Students

Megan Dang

Megan Dang

SEEDS Fellow, Women's Board Scholar
Joined White Lab in 2015
Bioengineering Class of 2017
Previous Research:

  • National Institutes of Health Pathways Intern, Bethesda, MD
    Performed procedures and isolation of cells required for the diagnostic of bacteria in non-human primates

Adam Berger

Adam Berger

HHMI Fellow, Goldwater Scholar
Joined White Lab in 2015
Bioengineering Class of 2017
RISE Program, Departmental Honors
Previous Research:

  • Crane Lab, Naval Medical Research Center, Silver Spring, MD
    In vivo biomedical Raman Spectroscopy and chemometrics to predict combat wound healing complications

Kenya Colvin

Kenya Colvin

LSAMP Fellow, ASPIRE Fellow
Joined White Lab in 2015
Chemical Engineering Class of 2018

Our Previous Lab Members

Ken Sharp

Ken Sharp

Production Technician at Trevigen
Masters Student in the White Lab, 2015-2016

Sean Virgile

Sean Virgile

Co-founder and CFO of Diagnostic anSERS, a company utilizing technology he helped develop while in the White Lab
Doctoral Student in the White Lab, 2010-2015

Dr. Kunal Pandit

Dr. Kunal Pandit

Research Engineer at New York Genome Center
Doctoral Student in the White Lab, 2012-2015

Dr. Eric Hoppmann

Dr. Eric Hoppmann

Data Scientist at Earth Networks
Co-founder and Former CEO of Diagnostic anSERS, a company utilizing technology he helped develop while in the White Lab
Doctoral Student in the White Lab, 2008-2013

Dr. Soroush Yazdi

Dr. Soroush Yazdi

Senior Biomedical Engineer at Medtronic
Doctoral Student in the White Lab, 2009-2013

Dr. Wei "VeeMoon" Yu

Dr. Wei "VeeMoon" Yu

Co-founder and Lead Scientist of Diagnostic anSERS, a company utilizing technology he helped develop while in the White Lab
Postdoctoral Research Associate in the White Lab, 2013-2014
Doctoral Student in the White Lab, 2008-2013

Dr. Jeffrey Burke

Dr. Jeffrey Burke

Principal Engineer at Circulomics Inc
Postdoctoral Research Associate in the White Lab, 2011-2013

Dr. Katayoon Saadin

Dr. Katayoon Saadin

Complex Microbial Systems Group at the National Institute of Standards and Technology
Former Clinical Research Associate at LifeBridge Health
Former Biotechnology Consultant for the University System of Maryland
Doctoral Student in the White Lab, 2009-2012

Dr. I-Jane Chen

Dr. I-Jane Chen

Staff Engineer at Becton Dickonson
Former R&D Engineer, Microfluidics Team at Caliper Life Sciences
Postdoctoral Research Associate in the White Lab, 2008-2011

Outreach

High School Interns from John F. Kennedy High School, Silver Spring, MD

Each year our lab hosts one intern from JFK high school. The students experience the excitement of the daily problem-solving challenges that are an inherent part of a career in engineering, and they achieve a sense of accomplishment through their work in our lab.

2015-2016: Trulee Riley

Trulee utilized MATLAB to develop software tools for data analysis in the lab.

2014-2015: Bernard Mkumbuzi

Bernard worked with microcontrollers to develop new instrumentation for the lab.

2013-2014: S. Justin Prasai

Justin investigated protocol variations in the synthesis of silver nanoparticles and the effect of these variations on surface enhanced Ramans spectroscopy.

2011-2012: Cataysha Lee

Cataysha studied the chemical functionalization of cellulose paper for biosensing applications.

2010-2011: Emilio Garcia

Emilio assisted Dr. White's lab by developing and testing material for the dual-credit engineering math course. In particular, Emilio worked with calculator-controlled robots that can assist with the teaching of mathematical principles.

2009-2010: Rhitu Risal

During her internship, Rhitu was tasked with attempting a number of different synthesis technics for gold and silver nanoparticles. She is currently studying chemistry at Barnard College in New York, NY, and is on her way to becoming a first-generation college graduate.

Teaching mathematics for engineers to high school students

Dr. White assisted the College of Education (Prof. Leigh Abts) and the Department of Defense (Jennifer Wolk, U.S. Navy, course instructor) to offer a dual-credit class to high school students that teaches mathematics for future engineering students through a hands-on approach.  The class aimed to attract more students into top-tier engineering programs and to provide these students with the necessary skills to survive the challenges of the undergraduate engineering curriculum.

News

(August 24, 2016) Adam Berger has been named a Philip Merrill Presidential Scholar in recognition of his academic excellence.

(August 10, 2016) Adam Berger has received the BMES Undergraduate Design and Research Award for his work on therapeutic drug monitoring with paper SERS devices. The award will be presented at the 2016 BMES conference.

(April 25, 2016) Megan Dang has been awarded the SEEDS undergraduate research fellowship from summer 2016 and the 2016-2017 academic year.

(April 22, 2016) Kenya Colvin has been awarded the ASPIRE undergraduate research fellowship to continue her research in summer 2016.

(April 7, 2016) Adam Berger has been awarded the Dinah Berman Memorial Award for his combined academic excellence and service to the Clark School.

(April 7, 2016) Adam Berger has been awarded the Fischell Department of Bioengineering Outstanding Junior Award.

(April 6, 2016) Adam Berger has won a UMD HHMI summer research fellowship!

(March 31, 2016) Adam Berger is named a national Goldwater Scholar.

(February 4, 2016) John Goertz passed his Ph.D. proposal! Congratulations!

(August 6, 2015) Stephen Restaino passed his Ph.D. proposal! Congratulations!

(July 9, 2015) Adriel Sumathipala is selected as a regional finalist in the Google Science Fair.

(May 21, 2015) Kunal Pandit successfully defended his Ph.D. dissertation! Congratulations!

(March 31, 2015) Hieu Nguyen has been awarded the prestigious NSF Fellowship! Congratulations!

(March 13, 2015) Imaly Nanayakkara (Bioengineering Ph.D. student) and Hieu Nguyen (Bioengineering Ph.D. student) have joined our group.

(February 18, 2015) Our lab wins a MIPS award supported by the state of Maryland and Diagnostic anSERS.

(June 5, 2014) Kristen Giles passes her Bioengineering Undergraduate Honors thesis defense.

(May 14, 2014) Stephen Restaino wins the Distinguished Graduate Student Teaching Award from the University of Maryland Center for Teaching Excellence.

(March 10, 2014) Kristen Giles wins Best Undergraduate Research Poster Award at the Mid-Atlantic Micro/Nano Alliance annual symposium.

Giles Award

(January 1, 2014) John Goertz, the 2013 winner of the Fischell Fellowship, has joined the group.

Eric Hoppmann successfully defended his Ph.D. dissertation. Congratulations!

Soroush Yazdi successfully defended his Ph.D. dissertation. Congratulations!

Veemoon Yu was awarded the Fischell BIOE Outstanding Graduate Researcher for 2012-2013.

Kristen Giles has been accepted into the BIOE Honors Program.

Veemoon Yu successfully defended his Ph.D. dissertation. Congratulations!

Hoppmann wins GRID competition with presentation on paper-SERS detection of PCR products.

Virgile, Diagnostic anSERS, take third at the national Cupid's Cup Competition.

Our lab wins a MIPS award, supported by the state of Maryland and Diagnostic anSERS.

Yu's paper on inkjet-printed paper SERS dipsticks, swabs, and lateral flow concentration is selected for Analyst outside front cover.

Analyst front cover

Hoppmann, Virgile win Dingman Pitch Competition.

Katayoon Saadin successfully defended her Ph.D. dissertation. Congratulations! She is the first graduate from our research group.

Hoppmann, Virgile reach finals of MTECH's $75K Business Plan Competition.

Our group wins a collaboration award from the FDA Center of Excellence in Regulatory Science and Innovation.

Our paper-based SERS devices were featured by SPIE Newsroom.

Yazdi's optofluidic SERS paper selected for the Virtual Journal of Nanoscale Science and Technology and the Virtual Journal of Biological Physics Research.

Our group wins a Blue Ocean Grant from Ocean Optics.

Fischell Institute of Biomedical Devices establishes partnership with Canon US Life Sciences.

Chen publishes record detection limit for interdigitated array microelectrode electrochemical biosensor.

Yu wins best presentation in session at Graduate Research Interaction Day (GRID).

Sean Virgile, the 2010 winner of the Fischell Fellowship, has joined the group.

C&EN reports on Yu's ink-jet-printed SERS array.

Yu publishes first ever ink-jet-printed SERS microdevice.

SERS on paper image

Available Positions

Post-Doctoral Associates

Currently we do not have any post-doc positions available.

Graduate Students

In the Fischell Department of Bioengineering, graduate students do not select research groups until the end of their first year. Therefore, if you are interested in joining our group, please first apply for admission to the department.

Undergraduate Students

Currently we do not have any undergraduate research positions available.

Publications

Peer-Reviewed Publications

  1. Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035

  2. Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006

  3. Kunal R. Pandit, Paul E. Rueger, Richard V. Calabrese, Srinivasa R. Raghavan, and Ian M. White, Assessment of surfactants for efficient droplet PCR in mineral oil using the pendant drop technique, Journal of Colloids and Surfaces B: Biointerfaces, 126, 489-495, 2015. DOI:10.1016/j.colsurfb.2015.01.001

  4. Jeffrey M. Burke, Kunal Pandit, John P. Goertz, and Ian M. White, Fabrication of rigid microstructures with thiol-ene-based soft lithography for continuous-flow cell lysis, Biomicrofluidics, 8, 056503, 2014. DOI:10.1063/1.4897135.

  5. Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Multiplex detection of DNA targets using polymerase chain reaction (PCR) and paper surface enhanced Raman spectroscopy (SERS) chromatography, Applied Spectroscopy, 68, 909-915, 2014. DOI:10.1366/14-07451.

  6. Jeffrey M. Burke, Rebecca E. Zubajlo, Elisabeth Smela, and Ian M. White, High-throughput particle separation and concentration using spiral inertial filtration, Biomicrofluidics, 8, 024105 2014. DOI:10.1063/1.4870399.

  7. Jordan F. Betz, Wei W. Yu, Yi Cheng, Ian M. White, and Gary W. Rubloff, Simple SERS substrates: powerful, portable, and full of potential, Physical Chemistry Chemical Physics, 16, 2224-2239, 2014. DOI:10.1039/C3CP53560F.

  8. Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Inkjet-printed fluidic paper devices for chemical and biological analytics using surface enhanced Raman spectroscopy, Journal of Selected Topics in Quantum Electronics, 20, 7300510, 2014. DOI:10.1109/JSTQE.2013.2286076.

  9. Soroush H. Yazdi, Kristen L. Giles, and Ian M. White, Multiplexed detection of DNA sequences using a competitive displacement assay in an microfluidic SERRS-based device, Analytical Chemistry, 85, 10605-10611, 2013. DOI:10.1021/ac402744z.

  10. Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Highly sensitive and flexible inkjet printed SERS sensors on paper, Methods, 63, 219-224, 2013. DOI:10.1016/j.ymeth.2013.07.010.

  11. Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, 138, 3679-3686 2013. DOI:10.1039/C3AN00673E.

  12. Katayoon Saadin, Jeffrey M. Burke, Neerav P. Patel, Rebecca E. Zubajlo, and Ian M. White, Enrichment of tumor-initiating breast cancer cells within a mammosphere-culture microdevice, Biomedical Microdevices, 15, 645-655, 2013. DOI:10.1007/s10544-013-9755-y.

  13. Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)

  14. Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, in press, DOI:10.1039/C2AN36232E.

  15. Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.

  16. Soroush H. Yazdi and Ian M. White, An Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Chemical Contaminants, Analytical Chemistry, 84, 7992-7998, 2012. DOI:10.1021/ac301747b.

  17. Katayoon Saadin and Ian M. White, Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications, Expert Reviews of Molecular Diagnostics, 13, 49-60, 2013. DOI:10.1586/erm.12.117.

  18. Ian M. White, Soroush H. Yazdi, and Wei W. Yu, Optofluidic SERS: synergizing photonics and microfluidics for chemical and biological analysis, Microfluidics and Nanofluidics, 12, 205-216, 2012. DOI:10.1007/s10404-012-0962-2

  19. Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.

  20. Soroush H. Yazdi and Ian M. White, A nanoporous optofluidic microsystem for highly sensitive and repeatable SERS detection, Biomicrofluidics, 6, 014105, 2012. DOI:10.1063/1.3677369. (selected for publication in the Virtual Journal of Nanoscale Science and Technology and the Virtual Journal of Biological Physics Research)

  21. Xudong Fan and Ian M. White, Optofluidic microsystems for chemical and biological analysis, Nature Photonics, 5, 591-597, 2011. DOI:10.1038/nphoton.2011.206.

  22. I-Jane Chen and Ian M. White, High-sensitivity electrochemical enzyme-linked assay on a microfluidic interdigitated microelectrode, Biosensors and Bioelectronics, 26, 4375-4381, 2011. DOI:10.1016/j.bios.2011.04.044.

  23. Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.

  24. Jikun Liu, Ian M. White, and Don L. DeVoe, Nanoparticle-Functionalized Porous Polymer Monolith Detection Elements for Surface-Enhanced Raman Scattering, Analytical Chemistry, 83, 2119-2124, 2011. DOI:10.1021/ac102932d.

Technical Conferences

Affiliations

Fischell Department of Bioengineering

Maryland Microsystems Initiative

Institute for Systems Research

Maryland Nanocenter

Sponsors