Event
BIOE Seminar: 3D printed scaffolds and implants for bone regeneration and drug delivery
Thursday, March 6, 2025
11:00 a.m.-12:00 p.m.
A. James Clark Hall, Room #4104
John Fisher
jpfisher@umd.edu
Susmita Bose
Westinghouse Distinguished Chair Professor
Washington State University
3D printed scaffolds and implants for bone regeneration and drug delivery
Abstract
Current clinical approaches to treating bone defects involve bone transplantation or synthetic materials to repair and restore functionality. 3D Printing (3DP) or additive manufacturing (AM) technology can produce patient-matched implants for special anatomical needs or concerns related to specific defect size complexity. However, establishing process property relationships for different AM techniques is vital to successfully implementing these manufacturing practices in biomedical devices. Calcium phosphate (CaP) ceramics, compositionally similar to the inorganic part of bone, show significant promise for implant applications in 3DP scaffolds and surface-modified hip and knee implants. Chemistry plays a vital role in controlling the degradation kinetics, mechanical strength, and biological properties of these CaPs. Natural medicinal compounds (NMCs) loading on 3DP CaP scaffolds and coatings on Titanium show improved osteogenesis, angiogenesis, and controlled drug delivery, using in vivo studies in rat distal femur model. Polymer encapsulation and metal ion complexation of these NMCs support bioavailability and release kinetics, showing antibacterial properties and reducing osteosarcoma cell proliferation. These systems show promise for their use in orthopedic and dental devices while eliminating the need for autografts and the second site surgery for harvesting and improving current hip/knee implant lifetime.
Speaker Bio
Susmita Bose is a Westinghouse Distinguished Chair Professor of the School of Mechanical and Materials Engineering, affiliate faculty of Chemistry, and Elson Floyd College of Medicine at Washington State University. She is a fellow of the American Association for the Advancement of Science (AAAS), National Academy of Inventors (NAI), Materials Research Society (MRS), ASM International, American Institute for Medical and Biological Engineering (AIMBE), American Ceramic Society (ACerS), Royal Society of Chemistry (RSC), an elected board member of the Washington State Academy of Sciences (WSAS). Among other awards, she also received the NSF CAREER/PECASE award, which is given at the White House by the US President.
Prof. Bose has supervised over 45 graduate students for MS and PhD. She has published over 340 technical articles, >290 journal articles, 24 book chapters, 9 edited books, 13 issued patents at the interface of Materials Science, Mechanical Engineering, Chemistry, and Bioengineering, focusing on additive manufacturing or 3D Printing, implant materials, and drug delivery, with citations about 39,000 times, "h" index 99 (Google Scholar). Her group's research on 3D-printed bone tissue engineering scaffolds and natural medicine has been featured by the AP, BBC, NPR, CBS News, MSNBC, ABC News, R&D magazines, Science Daily News, and many other TV, radio stations, and news sites worldwide.
Other interests: Prof Bose loves learning about natural medicinal compounds and Indian Classical music/Noble Laureate Tagore songs. She gives guest lectures in Music classes at the WSU School of Music and Honors College.
