BIOE Seminar Series: Dr. Juliane Nguyen
Wednesday, November 8, 2017
10:00 a.m.-11:00 a.m.
Room 1107, Jeong H. Kim Engineering Building
Dr. Steven Jay
Dr. Juliane Nguyen
Department of Pharmaceutical Sciences
University at Buffalo, The State University of New York
Activity-Composition Analysis of Exosomes
One of the most attractive features of exosomes is their ability to transfer cargo to recipient cells and in doing so modify cellular phenotypes. microRNAs (miRNAs), which regulate the expression of approximately 30-70% of human genes through base-pairing of their “seed” sequences with complementary mRNA, make up an important fraction of exosomal content. Thus, it is not surprising that miRNAs are key contributors to the overall biological function of exosomes. However, exosomes contain diverse and numerous miRNAs, making it difficult to establish the contributory effects of individual miRNAs to the overall phenotypic response. This talk will describe our efforts to establish the biological functions of exosomes through miRNA profiling and network analyses.