BIOE Seminar: Frederick Epstein
Friday, November 2, 2018
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2132
Dr. Giuliano Scarcelli
Dr. Frederick Epstein
Professor and Chair of Biomedical Engineering
Professor of Radiology
University of Virginia
MRI in mouse models of heart disease
Genetically modified mice are widely used to study biological mechanisms of normal physiology and heart disease. Magnetic resonance imaging (MRI) is a modality that can accurately and reproducibly measure cardiac anatomy, function, perfusion, infarction, and certain cellular and molecular events. Our research involves the development and optimization of cardiac MRI methods for mice as well as their application in hypothesis-driven research. This seminar will present an overview of MRI methods that we have developed to image various aspects of cardiovascular physiology in mice, with a focus on quantification of function, blood flow, and tissue properties. The application of these methods in mouse models of left ventricular remodeling after myocardial infarction and in coronary microvascular disease will be presented.
About the Speaker
Frederick H. Epstein, Ph.D., Mac Wade Professor of Biomedical Engineering and Radiology and Chair of Biomedical Engineering at the University of Virginia (UVA), is recognized for contributions to magnetic resonance imaging of the heart in humans and mouse models of heart disease. Dr. Epstein has published over 120 peer-reviewed articles, was an Established Investigator of the American Heart Association (AHA), and has served as Chair of the Society for Cardiovascular Magnetic Resonance (SCMR) Science Committee and the International Society for Magnetic Resonance in Medicine (ISMRM) Cardiac Study Group. He has also served on the SCMR Board of Trustees. He is currently a Deputy Editor for Magnetic Resonance in Medicine and past Chair of the American Institute for Medical and Biological Engineering (AIMBE) Academic Council. He is a Fellow of the ISMRM, the AHA, and AIMBE, and he is Principle Investigator of the UVA Coulter Translational Research Partnership. He recently completed a term as a standing member of NIH Study Section Biomedical Imaging Technology – A. In addition to academia, he has worked as a scientist/engineer at GE Medical Systems.