BIOE Big Ten Seminar: Jan Stegemann
Friday, November 9, 2018
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2132
Dr. Giuliano Scarcelli
Dr. Jan Stegemann
Associate Chair for the Masters Program, Biomedical Engineering
Professor, Biomedical Engineering
University of Michigan
Specialized Matrix Modules for the Fabrication of Multiphase Engineered Tissues
This talk will describe an innovative biomaterials-based system designed to deliver therapeutic cells to sites of injury. The focus will be on regeneration of vascularized bone tissue via delivery of osteogenic and vasculogenic progenitor cells to large bone defects. We have developed a method to embed cells in protein-based microenvironments that provide the structure and support of a 3D extracellular matrix while also presenting instructive cues through cell-matrix interactions. Importantly, these modules are in the form of discrete “microbeads” (∼100-300 µm in diameter), which can be created and cultured separately, but can be combined and concentrated into a multi-component paste for direct delivery to the site of injury, without the need to disrupt cell-matrix contacts. Our results demonstrate that modular microtissues can be used to augment the differentiated function of MSC, and to provide a suitable extracellular environment to promote bone repair and integration, while also allowing guided and minimally-invasive delivery to defect sites. Our approach combines advances in modular tissue engineering with promising aspects of progenitor cell therapy to create injectable, multifunctional tissues that could improve the treatment of large and recalcitrant bone defects.
About the Speaker
Jan P. Stegemann is Professor and Associate Chair for Master’s Programs in the Department of Biomedical Engineering at the University of Michigan in Ann Arbor. He received BS and MS degrees in Chemical Engineering from the University of Toronto. Prior to earning his PhD in Biomedical Engineering from the Georgia Institute of Technology, Dr. Stegemann worked for five years at Boston-based W.R. Grace & Co., where his research focused on cell-based bioartificial organs. Dr. Stegemann’s current research focuses on the use of extracellular environments to control cell function and the development of engineered tissues. Dr. Stegemann is highly active in several professional societies related to biomaterials and regenerative medicine, including the Biomedical Engineering Society (BMES), the Americas Chapter of Tissue Engineering and Regenerative Medicine International Society (TERMIS-AM), the US Society for Biomaterials (SFB). As an educator, Dr. Stegemann has developed and teaches courses in cell-matrix interactions, tissue engineering, and medical product development.