BIOE Seminar: Janet Zoldan
Friday, April 19, 2019
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2132
Dr. Giuliano Scarcelli
Dr. Janet Zoldan
Department of Biomedical Engineering
University of Texas, Austin
The Role of Biophysical And Biochemical Cues In Engineering Stem cell Microenvironments
Stem cells are becoming an important component of approaches for regenerative medicine, especially within the rapidly expanding field of tissue engineering. To unlock the full therapeutic potential of these cells, it is necessary to develop new approaches to direct their in-situ growth and differentiation towards functional tissue. In this talk, I will describe efforts to achieve this aim by developing extracellular stem cell microenvironments designed to present biophysical and biochemical cues to direct stem cell differentiation to cardiovascular lineage. First, I will describe the development extracellular stem cell microenvironment with incorporated anisotropy, as a biophysical cue, and the response of developing cardiomyocytes to substrate anisotropy. Second, I will demonstrate the impact of high glucose, as a biochemical cue, on cardiovascular specification and maturation. These engineered environments can serve as platforms for fundamental research in tissue development, disease mechanisms, or drug testing and hold potential for in-situ tissue regeneration applications.
About the Speaker
Dr. Zoldan received her BSc degree in chemistry from the Hebrew University, and then pursued her master’s degree and doctorate in the Technion-Israel Institute of Technology, Department of Materials Engineering, specializing in polymer science. For her postdoctoral training, she joined Dr. Robert Langer’s lab at the Massachusetts Institute of Technology. In the Langer lab, she focused on nucleic acid delivery to human embryonic stem cells and protein microfluidic delivery. In 2013 Dr. Zoldan joined The University of Texas at Austin as an assistant professor. Research in the Zoldan lab focuses on human induced pluripotent stem cells as a model system to explore key principles underlying cardiovascular tissue formation processes and regenerating ischemic tissue. She has recently received the prestigious Scientist Development Grant from the American Heart Association and was named a 2017 Emerging Investigator by the Journal of Biomaterials Science.