CANCELED - BIOE Seminar: Dr. Sharon Gerecht

Friday, April 17, 2020
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2132
Emily Rosenthal
301 405 3936

Dr. Sharon Gerecht

Director, Institute for NanoBio Technology

Professor of Materials Science and Engineering

Johns Hopkins University

Guiding 3D Vascular Fate and Assembly

Vascular differentiation and formation (morphogenesis) takes place in an intricate milieu. This unique microenvironment is situated throughout the body in diverse types of healthy tissues, yet it seems to activates/inhibits similar mechanisms of the microvasculature. Two parameters of this microenvironment seem critical for blood vessel growth and stabilization: (i) the extracellular matrix, which provides critical support for vascular cell adhesion, proliferation, migration, and morphogenesis, and (ii) low oxygen concentrations (hypoxia), which is a critical factor promoting vascularization during embryonic development and tumor growth. In this talk I will present our recent efforts to understand how these physicochemical cues and downstream signaling pathways impact vascular fate and assembly from progenitors and pluripotent stem cells.

About the Speaker:

Dr. Gerecht is professor of Chemical and Biomolecular Engineering
and director of The Institute for NanoBioTechnology at Johns Hopkins University.
Dr. Gerecht’s research group studies the interactions between cells and their
microenvironments with the long-term goal of engineering artificial cell
microenvironments capable of guiding homeostasis or regeneration. Dr. Gerecht
is the recipient of the Allan C. Davis Medal from the Maryland Academy of
Sciences (2008), the North America Vascular Biology Organization Junior
Investigator Award (2009), the Basil O’Connor Starter Scholar Research Award
from the March of Dimes Foundation (2009-2011), the National Scientist
Development Award (2008-2012) and Established Investigator Award (2014-
2019) both from the American Heart Association, the National Science
Foundation CAREER award (2011-2016), the W.W. Smith Charitable Trust Heart
award (2014-2017), and the Johns Hopkins University Inaugural President’s
Frontier Award (2015). Dr. Gerecht is an elected Fellow of the American Institute
for Medical and Biological Engineering (2016) and elected Member of the
National Academy of Medicine (2019). Dr. Gerecht is the author of more than
150 papers, book chapters, and patents in her field and a co-founder of
Gemstone Biotherapeutics, LLC, a spin-off company based on technologies
developed in her lab, focusing on wound healing.

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