BIOE Seminar Series: Sam Senyo (Case Western Reserve University)

Friday, November 6, 2020
9:00 a.m.-10:00 a.m.
Virtual
Steven Jay
smjay@umd.edu

Join us for the Bioengineering Seminar Series, which connects experts from around the country with our faculty, students, and staff to discuss their recent findings. Everyone is welcome!

The Fall 2020 seminars will be held virtually on Fridays from 9:00 a.m. – 9:50 a.m., unless otherwise noted. All BIOE faculty, students, staff, postdocs, and affiliates as well as additional subscribers to our weekly seminars emails will receive Zoom event information the week of each seminar. 

If you do not yet receive our weekly seminars email and would like to subscribe to the listserv, or if there is a particular seminar listed below that you would like to attend, please email Emily Rosenthal

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Dr. Sam Senyo
Assistant Professor
Department of Physiology & Biophysics
Case Western Reserve University

Abstract:

Mechano-biological modification of the ECM stimulates cardiac regeneration

Cardiac regeneration is a biological feature of lower vertebrates and a clinical aspiration that requires comprehensive understanding of cellular plasticity in the heart. One primary challenge is the limited proliferation potential of cardiomyocytes which stops shortly after birth. Inspired by heart formation during fetal development, a central hypothesis is that cell interactions with the extracellular matrix and paracrine signaling can drive cardiogenesis. Given the complexity of parsing out this signal in vivo, the Senyo lab seeks to address medical challenges of the heart based on understanding of the microenvironment niche and bench platforms to manipulate cellular interactions in a controlled manner. Using decellularization and microfluidics, specific cell interactions with extracellular matrix and adjacent cells can be investigated directly. This seminar will primarily focus on the hypothesis that fetal cues including soluble factors and softer substrates of the developing heart can reactivate stalled cardiomyocyte proliferation in injured postnatal hearts towards regeneration. Primary cells, cardiac explants, and animals were exposed to decellularized heart tissue in a modified mechanical environment to determine if recapitulating an early-stage environment influenced regenerative activity. Relative to adult cues, the fetal associated stimuli potentiate some regenerative indices including cardiogenesis, vascularization, and anti-fibrotic activity. We are now evaluating molecular mechanisms playing a role in these phenomena and most importantly considering clinical implications.

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