Event

Biodegradable polymeric nanoparticles can be engineered as advanced therapeutics for
intracellular delivery and in situ cellular engineering, leading to new paradigms for
genetic medicine. Libraries of biodegradable polymeric nanoparticles were constructed
and screened for the safe and effective intracellular delivery of DNA, miRNA, siRNA,
and proteins. Differential polymer structure was found to significantly increase
transfection efficacy and enable long-term in vivo gene expression. Tuning biomaterial
structure also enables cell-type specificity of nanoparticles in a range of cell types. 
Applications will be shown for non-viral ocular gene therapy, cancer stem cell
reprogramming, gene editing, and immunotherapy. These safe and effective
biodegradable nanoparticles are promising as enabling technology to treat diverse human
diseases.

Speaker Bio:

Dr. Jordan J. Green is a Professor of Biomedical Engineering, Ophthalmology,
Neurosurgery, Oncology, Materials Science & Engineering, and Chemical &
Biomolecular Engineering at the Johns Hopkins University School of Medicine. He is the
Vice Chair for Research and Translation in Biomedical Engineering and is the former
Director of the Biomedical Engineering Undergraduate Program at JHU. Dr. Green is
also the founding Associate Director of the Translational Tissue Engineering Center and
the founding Associate Director of Translational Immunoengineering Center at JHU. Dr.
Green received his B.S. in Chemical Engineering and in Biomedical Engineering from
Carnegie Mellon University in 2003 and completed his Ph.D. in Biological Engineering
from MIT. Subsequently, Dr. Green was a postdoctoral associate at MIT from 2007-
2008. Dr. Green was the founding CEO of the biotech company AsclepiX Therapeutics
and currently serves as a member of the Board of Directors. He also co-founded and/or
serves on the board of four other biotechnology companies. He is a Fellow of the
National Academy of Inventors, the Biomedical Engineering Society, the American
Institute for Medical and Biological Engineering, and the Controlled Release Society. He
is also an Associate Editor at Science Advances and a standing member of the NIH
NANO study section. His work has resulted in the publication of over 150 scientific
papers, 86 issued or pending patents, and 130 invited talks, and he has received numerous awards including the AIChE Colburn Award, the BMES Rita Schaffer Award, the
Presidential Early Career Award for Scientists and Engineers, Popular Science’s Brilliant
Ten, and was a National Academy of Medicine Emerging Leader Scholar in Health &
Medicine. Dr. Green and his lab are innovating gene therapies, immunotherapies, and cell
therapies to advance medicine.