PhD Dissertation - Robert Choe

Wednesday, October 4, 2023
12:00 p.m.
Rachel Chang
301 405 8268

Title: Enhancing Bioprinting Strategies Towards the Development of Biomimetic Osteochondral Tissue Engineering Scaffolds


Committee members:

Dr. John Fisher, Chair

Dr. Helim Aranda-Espinoza

Dr. Tao Lowe

Dr. Jonathan Packer

Dr. Isabel Lloyd, Dean's Representative



Osteoarthritis is a highly prevalent rheumatic musculoskeletal disorder that affects approximately 900,000 Americans annually and is characterized by the progressive breakdown of the articular cartilage and remodeling of the subchondral bone in the synovial joint. During early-stage osteoarthritis, the articular cartilage begins to degrade, the synovial joint space narrows, and the subchondral bone undergoes rapid bone turnover that leads to insufficient bone mineralization and compromised matrix integrity. While decades of research have revealed that an intricate balance between the bone and cartilage layers influences biochemical and biomechanical changes experienced within the osteochondral unit, most osteochondral tissue engineering scaffolds have not achieved clinical viability. Tissue engineering (TE) strategies, such as 3D bioprinting (3DP), offer a new avenue to help develop novel osteochondral tissue engineering scaffolds that can regenerate both healthy and diseased osteochondral joints. In this project, our immediate goal is to further expand the repertoire of osteochondral bioprinting strategies toward the development of a biomimetic, 3D-printed osteochondral scaffold. We will explore the designs and fabrication strategies of various 3D-printed biomimetic osteochondral interface scaffolds with enhanced mechanics guided by computational simulations. Additionally, we will examine the potential of utilizing osteoblast- and osteoclast-lineage cell co-cultures to enhance regenerative outcomes at the bone scaffold layer of osteochondral tissue engineering scaffolds. The long-term goal of this work is to aid in the development of a biomimetic 3D printed osteochondral scaffold that has enhanced load-bearing properties and elevated regeneration potential to recreate the unique osteochondral architecture at each distinct tissue layer.

Audience: Graduate  Faculty  Staff  Parents and Family 

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