Event
BIOE Seminar: Tissue Engineered Vascular graft Design for Use in Congenital Heart Surgery
Friday, October 27, 2023
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room #2121
Steven Jay
smjay@umd.edu
Christopher Breuer
Nationwide Children's Hospital
Endowed Chair in Surgical Research
Development and Translation of a Tissue Engineered Vascular Graft Design for Use in Congenital Heart Surgery
Abstratct
Taken together congenital cardiac anomalies represent the most common birth defect affecting 1% of all live births. Despite significant advances in the medical and surgical management of patienst with congenital heart disease, it remains a leading cause of death in the newborn period and a significant source of life-long morbidity in survivors. Most major congenital heart operations require the use of man-made materials in the form of cardiovascular patches, vascular grafts, or replacement heart valves. Use of bioprosthetics are a significant source of thrombo-embolic complications, the most common serious postoperative adverse event associated with congenital heart surgery. In addition, they have poor durability due to ectopic calcification and somatic overgrowth. Finally, they are also susceptible to infectious complications. The development of autologous tissue engineered biomaterials holds the potential to create improved bioprosthetics which could reduce the incidence of complications and improve long term outcomes of infants and children with congenital heart disease. Herein we will update the audience of the current state of the development and translation of tissue engineered constructs for use in congenital heart surgery.
Speaker Bio
Christopher K. Breuer, MD, is director of the Center for Regenerative Medicine at Nationwide Children's Hospital, Nationwide Endowed Chair in Surgical Research and director of Tissue Engineering in The Ohio State University Wexner Medical Center's new Center for Regenerative Medicine and Cell Based Therapies. His clinical and research interests center on bioengineered tissue for use in surgery. Working with Dr. Toshiharu Shinoka, he was the first in the world to tissue engineer blood vessels and implant them in human infants. Dr. Breuer has many honors recognizing his contributions, including the Jacobsen Promising Investigator Award from the American College of Surgeons which is given to the most innovative young surgical investigator in the country.
