Event
BIOE Seminar: Self-Tolerance and Immunoregulation after Traumatic Soft Tissue Injury
Friday, April 19, 2024
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room #2121
Katharina Maisel
maiselka@umd.edu
Dr. Kaitlyn Sadtler
Investigator, Chief of Section on Immunoengineering
National Institute of Biomedical Imaging and Bioengineering, NIH
Self-Tolerance and Immunoregulation after Traumatic Soft Tissue Injury
Abstract
During trauma and surgical reconstruction there is a disruption of homeostasis, release of self-antigen, and induction of inflammatory processes. This inflammation is meant to clear debris, prevent infections, and initiate wound healing. With the increased inflammation and release of self-antigen, central and peripheral tolerance are at play to prevent autoimmunity. As such we investigated the communications between innate and adaptive immunity to identify potential mechanisms of self-tolerance and how they are modulated in biomaterial-mediated muscle regeneration. Through use of a volumetric muscle loss (VML) model the lab has discovered that NK cells, cDC1s, pDCs, and regulatory CD8+ T cells play a central role in post-trauma self-tolerance. Through this study we have identified a new pathway mediating muscle wound healing and tissue regeneration with implications in future development of therapeutics both for tissue engineering and medical device development. This pathway has been found to be mis-regulated in a variety of autoimmune-like conditions suggesting a possible mechanism that links traumatic tissue injury with pathologies seen with more minor tissue damage. Work in human patients has identified multiple cytokine and chemokine changes after traumatic injury that are associated with autoimmune and tolerogenic responses including identification of a novel predictor of patient survival.
Speaker Bio
Kaitlyn Sadtler, Ph.D. joined NIBIB as an Earl Stadtman Tenure-Track Investigator and Chief of the Section for Immunoengineering in 2019. Prior to her arrival to the NIH, she completed a postdoctoral fellowship at the Massachusetts Institute of Technology with Daniel Anderson, Ph.D. and Robert Langer, Ph.D., focusing on the molecular mechanisms of medical device fibrosis. During her time at MIT, Dr. Sadtler was awarded an NRSA Ruth L Kirschstein Postdoctoral Fellowship, was listed on BioSpace’s 10 Life Science Innovators Under 40 To Watch and StemCell Tech’s Six Immunologists and Science Communicators to Follow. In 2018, she was named a TED Fellow and delivered a TED talk which was listed as one of the 25 most viewed talks in 2018. She was also elected to the 2019 Forbes 30 Under 30 List in Science, selected as a 2020 TEDMED Research Scholar, and received multiple other awards. Dr. Sadtler received her Ph.D. from the Johns Hopkins University School of Medicine where her thesis research was published in Science magazine, Nature Methods, and others. She was recently featured in the Johns Hopkins Medicine Magazine as an alumna of note. Dr. Sadtler completed her bachelor’s degree summa cum laude at the University of Maryland Baltimore County, followed by a postbaccalaureate IRTA at the Laboratory of Cellular and Molecular Immunology at NIAID
