Event
BIOE Seminar: Harnessing S1P Pathways and Immune Modulation for Regenerative Engineering
Friday, February 21, 2025
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room #2121
Erika Moore
emt@umd.edu
Ed Botchwey
Professor
Georgia Institute of Technology
Harnessing S1P Pathways and Immune Modulation for Regenerative Engineering: From Musculoskeletal Repair to Vascular Remodeling
Abstract
Recent studies from Dr. Botchwey’s lab explore the role of sphingosine-1-phosphate (S1P) signaling in tissue regeneration. This talk will highlight their innovative findings on ApoM-Fc, a novel S1P chaperone that improves muscle healing and reduces fibrosis in volumetric muscle loss (VML) models, as well as new strategies for cleft palate repair using nanofiber hydrogels. By combining metabolomic analyses, lipid signaling insights, and biomaterial-based drug delivery systems, these approaches address key challenges in tissue repair and immune modulation. The seminar will also touch on lipid dysregulation and immune responses in neurovascular and cognitive complications of sickle cell disease (SCD). Recent work leverages imaging, lipidomics, and advanced biomaterials to investigate the interplay between inflammation, vascular health, and disease progression.
Speaker Bio
Dr. Edward Botchwey is a Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. His work integrates bioactive lipid signaling, metabolomics, and biomaterials to advance regenerative medicine, inflammation resolution, and vascular health. Dr. Botchwey is dedicated to creating access and promoting excellence in STEM through programs such as SURE (Summer Undergraduate Research Experience) and ENGAGES (Engaging New Generations at Georgia Tech through Engineering and Science). These initiatives provide vital research opportunities to a diverse array of students, ensuring that talented individuals from all backgrounds can contribute to and benefit from advancements in regenerative engineering, vascular health, and beyond. His work demonstrates a convergence approach, tackling complex challenges through interdisciplinary collaboration and inclusive practices.
