Event
Bioengineering Seminar Series: Vladimir Muzykantov
Friday, March 2, 2012
11:00 a.m.-12:00 p.m.
Room 1200 Jeong H. Kim Engineering Bldg.
Professor Silvia Muro
muro@umd.edu
Targeting Biotherapeutics in the Vascular System
Vladimir Muzykantov
Professor of Pharmacology
University of Pennsylvania School of Medicine
Biotherapeutics including enzyme therapies gain increasing traction as a pharmacotherapy. They provide unique specificity and potency of action, yet their medical utility is restricted by rapid inactivation and necessity to be delivered precisely to the target sites in the body. We devise targeting approaches in which therapeutic enzymes are conjugated with affinity carriers providing anchoring and proper sub-cellular destination in the vascular endothelium and blood cells. This approach markedly improves the pharmacokinetics, targeting and effects of the enzyme therapies in animal models of oxidative stress, inflammation and thrombosis.
