Event
Bioengineering Seminar Series: Hisataka Kobayashi
Friday, March 15, 2013
11:00 a.m.-12:00 p.m.
Pepco Room, Jeong H. Kim Engineering Building
Professor Yu Chen
yuchen@umd.edu
Optical Imaging and Therapy Toward Clinical Applications
Hisataka Kobayashi
Chief Scientist
Molecular Theranostics Laboratory
Molecular Imaging Program
National Cancer institute/National Institutes of Health
In recent years, numerous molecular imaging probes have been developed and offered the possibility of in vivo target-specific information based on biology. In addition, molecular imaging probes especially focusing on each imaging modality, each material, or each target disease including cancer have been designed and synthesized based on physics and chemistry. More recently, a second generation of molecular imaging probes with unique or multi-functional characteristics has been designed. This lecture focuses on (i) molecular imaging modalities and signals, which employ the full range of the electromagnetic spectra from gamma-ray to microwave, based on physics, (ii) optimized chemical design of molecular imaging probes for in vivo kinetics based on biology and physiology, (iii) practical preclinical examples of activatable optical imaging probes for cancer detection and characterization. Additionally, I will discuss about our newly developed technology for the target-specific cancer therapy, photo-immunotherapy, evolved from the similar multi-disciplinary integrated technology of physics, chemistry, and biology.
References:
1. Kobayashi, H. & Choyke, P. L.: Acc Chem Res, 44: 83-90, 2011
2. Kobayashi, H., et al.: Chem Soc Rev, 40: 4626-4648, 2011
3. Kobayashi, H., et al.: Lancet Oncol, 11: 589-595, 2010
4. Kobayashi, H., et al.: Chem Rev, 110: 2620-2640, 2010
5. Mitsunaga, M., et al.: Nat Med, 17: 1685-1691, 2011
6. Urano, Y., et al.: Nat Med, 15: 104-109, 2009
7. Urano, Y., et al.: Sci Transl Med, 3: 110ra119, 2011
8. Ogawa, M., et al.: Cancer Res, 69: 1268-1272, 2009
9. Sano, K., et al.: ACS Nano, 7: 717-724, 2013.
