Event

Bioengineering Seminar Series: Heungsoo Shin

Friday, October 31, 2014
9:00 a.m.
Pepco Room (1105), Jeong H. Kim Engineering Building
Professor John Fisher
jpfisher@umd.edu

Heungsoo Shin, Ph.D.
Associate Professor
Department of Bioengineering
College of Engineering
Hanyang University

Biomimetic surfaces and materials for regenerative medicine

Biomaterials have been developed in regenerative medicine to perform multiple functions including rapid expansion of stem cells, delivery of therapeutic cells or drugs, or endogeneous induction of cell/tissue response upon implantation. Although synthetic biodegradable materials have been widely used in regenerative medicine, they are mostly hydrophobic and showed poor interactions with cells and native tissue. Therefore, many efforts have been made to develop biomimetic materials that can exhibit chemical, physical, biological, and structural characteristics similar to those of native extracellular matrix (ECM). ECM is composed of a number of biomacromolecules including proteins, glycosaminoglycans, and proteoglycans, which are assembled together to form complex 3-dimensional network.  Cells are bound to these ECM components, which in many cases, are implicated in critical cell fate process such as adhesion, proliferation, differentiation, and survival. In this presentation, the discussion will be focused on our approaches to develop cell-interactive biomimetic surfaces and materials for modulation of cell function and their use in regenerative medicine by providing several exemplary works focused on regeneration of bone and treatment of ischemic injuries.