Event
BIOE Seminar Series: Carlos Aguilar
Friday, March 30, 2018
9:00 a.m.-10:00 a.m.
A. James Clark Hall, Room 2132
Dr. Steven Jay
smjay@umd.edu
Dr. Carlos Aguilar
Assistant Professor, Biomedical Engineering
University of Michigan
Listening to and re-writing the molecular songs of muscle regeneration using integrative genomics and single-molecule sensors
This presentation will frame the genome as an ensemble of musical instruments and provide examples of how using integrative genomic assays enables quantitative evaluation of healing trajectory and therapeutic efficiency. In the first example, I will discuss regeneration of skeletal muscle from a murine model of mild trauma and perspectives of tissues, specific cell types and single cells. A ‘healing song’ will be described and used to quantitatively track the influence of different injury severities (volumetric muscle loss and peripheral nerve injuries) and how knockouts and regenerative therapies augment these harmonies. In the second example, I will introduce the engineering and use of solid-state nanopores for writing synthetic genes, which may open up avenues to write new healing melodies or different notes within existing songs. Last, I will briefly discuss current avenues of research in my new laboratory at Michigan bridging these disciplines to understand and ‘tune’ molecular responses for enhancements in skeletal muscle performance and aging reversal.
