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Bioengineering Seminar Series: Valeria Cavalli
Friday, October 15, 2010
11:00 a.m.-12:00 p.m.
Room 2108, Chemical and Nuclear Engineering Bldg.
For More Information:
Professor Sameer Shah
sameer@umd.edu

Axonal Transport and Nerve Regeneration

Valeria Cavalli
Assistant Professor of Neurobiology
Department of Anatomy and Neurobiology
Washington University School of Medicine, St. Louis, MO

Unlike neurons in the central nervous system (CNS), injured neurons in the peripheral nervous system (PNS) can regenerate their axons and reinnervate their targets. Injured peripheral neurons benefit from the absence of inhibitory signals in their environment and, in addition, activate intracellular signaling pathways that enable axonal regrowth. Injury signals elicited locally at the injury site convey information back to the cell bodies to increase the intrinsic growth capacity. In the first part of the talk, we will discuss how the scaffolding protein Sunday Driver contributes to the injury signaling pathways. In the second part, we will discuss how PNS neurons activate the master regulator of protein synthesis, mTOR, following damage and how this activity enhances axonal growth capacity.

This Event is For: Graduate • Faculty • Post-Docs

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