Event
Bioengineering Seminar Series: Zhongjun Wu
Friday, March 11, 2011
11:00 a.m.
Room 1200, Jeong H. Kim Engineering Building
Professor Sameer Shah
sameer@umd.edu
Development of Artificial Pump-Lung Technology:
From Concept to Bedside
Zhongjun Wu
Associate Professor of Surgery
Director, Artificial Organs Laboratory
University of Maryland School of Medicine
Lung disease, behind cardiovascular illness and cancer, is the third largest cause of death in America. Current therapy for respiratory failure includes mechanical ventilation and extracorporeal membrane oxygenation. Mechanical ventilation is effective for short term support, yet the sustained tidal volumes and airway pressures often used may damage the lungs via barotrauma, volutrauma, and other iatrogenic injuries that can prevent lung recovery. ECMO systems are attractive since they closely simulate physiological gas exchange, but in practice, these systems are limited by the complexity of its operation, bleeding, and reduced patient mobility. At present, irreversible and chronic lung disease can only be treated with lung transplantation. Unfortunately, lung transplantation is limited by the availability of donor lungs and the lack of bridge to transplantation options. The objective of this project is to develop novel compact integrated pump-lung technology to provide respiratory and/or cardiopulmonary support for patients with lung failure and heart/lung failure.
In this talk, we will provide a comprehensive survey of the current status and future perspective of artificial lung device as therapy for patients with respiratory failure. The fundamental technical problems associated with artificial organs and bioengineering principles used in the development of the integrated artificial pump-lung technology from the initial concept to bedside for clinical use will be presented.
