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Bioengineering Seminar Series: Srinidhi Nagaraja
Friday, March 16, 2012
11:00 a.m.-12:00 p.m.
Room 1200 Jeong H. Kim Engineering Bldg.
For More Information:
Professor Silvia Muro

Effects of Vertebroplasty on Adjacent Intervertebral Discs and Vertebrae in Osteopenic Spines

Srinidhi Nagaraja
Center for Devices and Radiological Health
Office of Science and Engineering Laboratories

Vertebral compression fractures (VCFs) are a significant public health concern affecting approximately 1.4 million individuals worldwide. Osteoporosis related VCFs are particularly a concern for elderly women as they affect 25% of all post-menopausal women in the United States and 40% of women over 80 years old. The most common surgical treatment for VCFs is percutaneous vertebroplasty, a minimally invasive procedure in which poly(methylmethacrylate) (PMMA) bone cement is injected into the fractured vertebral body to stabilize the fracture and relieve associated pain. Although this treatment option is currently the gold standard, approximately 20% of patients experience subsequent fractures within 6 months of the vertebroplasty surgery, and many of these fractures occur in vertebrae adjacent to the treated level. The significant rate of adjacent level fractures suggests that vertebroplasty may negatively impact spine biomechanics. This presentation will discuss FDA’s research efforts to better understand whether vertebroplasty alters thoracolumbar spine biomechanics, particularly in vertebrae and intervertebral discs adjacent to the augmented vertebra.

This Event is For: Graduate • Faculty • Post-Docs

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