Event
Bioengineering Seminar Series: Matthew Steinhauser
Friday, October 25, 2013
9:00 a.m.-10:00 a.m.
Pepco Room, Jeong H. Kim Engineering Building
Yu Chen
yuchen@umd.edu
Tracking Cell Turnover and Fate with Stable Isotope Tracers in Model Organisms and Humans
Matthew Steinhauser, M.D.
Instructor in Medicine, Harvard Medical School
Associate Physician of Cardiovascular Medicine, Brigham and Women's Hospital
This seminar will:
- Introduce multi-isotope imaging mass spectrometry (MIMS), which combines extreme imaging resolution with quantitation of stable isotope tracers in domains much smaller than a micron cubed.
- Describe proof-of-principle applications of MIMS to study cell division, including the testing of the immortal strand hypothesis in the small intestinal crypt.
- Show new data using MIMS and other mass spectrometry methodologies to study adipose tissue plasticity in mice and humans.
- The presentation will emphasize novel (and sometimes unexpected) insights that arise from quantitative studies on the single cell level.
About the Speaker
Matthew Steinhauser received his undergraduate and medical education from the University of Michigan, where he studied cytokine and chemokine networks in animal models of acute and chronic inflammation. He received clinical training in internal medicine at Columbia University Medical Center in New York City and cardiovascular medicine at Brigham and Womens Hospital in Boston. He completed postdoctoral training in Boston, where he took a lead role in applying imaging mass spectrometry to stem cell biology in the intestine and heart. His laboratory, which is housed at Harvard Medical School and the Brigham and Womens Hospital Division of Genetics, has a dual focus on understanding the role of adipose tissue plasticity in metabolic disease and the development of new approaches to studying cell turnover and fate using stable isotope tracers. He also continues to have an active clinical practice in the Brigham and Womens Hospital Cardiovascular Division.
