The Biomolecular and Metabolic Engineering Laboratories employ the tools of "functional" genomics to understand the regulation of genetic circuits during applied stresses. In particular, DNA microarrays are used for analyzing gene expression on a global basis. This, coupled with transcriptional promoter probes, quantitative RT-PCR, Northern and Western analyses ultimately enables close to real time detection of gene expression in targeted circuits. The group is currently focusing on stress-related and nutritionally- regulated pathways such as those involving s32, sS,and sN. The group's objective is to alter the intracellular environment to improve cellular processes, including the production of recombinant proteins. It is also developing new analytical tools to monitor gene expression both in vivo and in vitro.
William E. BentleyRobert E. Fischell Distinguished Professor
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