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Hsieh, Adam

Adam Hsieh
Associate Research Professor
3242 Jeong H. Kim Engineering Building

News About This Professor

Research Interests 

Orthopaedic biomechanics; soft tissue mechanobiology; mechanisms of intervertebral disc degeneration; mechanobiologic strategies for developing spatially-complex tissue engineered constructs.


Ph.D., University of California, San Diego, 2000

Current Research Projects 

  • Intervertebral disc mechanics
  • Intervertebral disc cell-ECM interactions
  • Intervertebral disc cellular engineering
  • Mesenchymal stem cell mechanotransduction

For more informaiton, please visit Professor Hsieh's web site »

Honors and Awards 

  • NSF CAREER Award, 2009
  • NIH Ruth L. Kirchstein National Research Service Award, 2001

Professional Memberships 

  • Organizer, 12th Annual Computational Methods in Orthopaedic Biomechanics (Pre-ORS), 2004

Selected Publications 

In review:

  • Strebe S, Kim H, Hsieh AH, Nascone JW, O’Toole RV. “Analysis of strategies to increase external fixator stability: is double stacking worth the cost?” J Trauma, submitted.
  • Boulton CL, Kim H, Shah SB, Ryan SP, Metzger TA, Hsieh AH, O’Toole RV. “Do Locked Screws Work in Bent Plates?” J Orthop Trauma, submitted.
  • Eagan M, Kim H, Manson TT, Gary JL, Russell JP, Hsieh AH, O’Toole RV, Boulton CL. “Internal Anterior Fixators (INFIX) for Pelvic Ring injuries: Do Monoaxial Pedicle Screws Provide More Stiffness than Polyaxial Screws?” J Orthop Trauma, submitted.

Rastogi A, Kim H, Twomey JD, Hsieh AH. “MMP-2 mediates local degradation and remodeling of collagen by intervertebral disc cells.” Arthritis Res Ther 15: R57, 2013. doi: 10.1186/ar4224. PMID: TBD

Hawks MA, Kim H, Strauss JO, Oliphant BW, Golden RD, Hsieh AH, Nascone JW, O’Toole RV. “Does a trochanteric lag screw improve fixation of vertically oriented femoral neck fractures? A biomechanical analysis in cadaveric bone” Clin Biomech, accepted. doi: TBD. PMID: TBD

Yew AG, Pinero D, Hsieh AH, Atencia J. “Low Peclet number mass and momentum transport in microcavities.” Appl Phys Lett 102: 084108, 2013.doi: 10.1063/1.4794058. PMID: n/a

Shahmirzadi D, Bruck HA, Hsieh AH. “Quantifying the interfibrillar spacing and fibrillar orientation of the aortic extracellular matrix using histology image processing: toward multiscale modeling.” IEEE Trans Biomed Eng 60(5): 1171-1180, 2013. doi: 10.1109/TBME.2012.2229708. PMID: 23192484.

Shahmirzadi D, Bruck HA, Hsieh AH. “Measurement of mechanical properties of soft tissues in vitro under controlled tissue hydration.” Exp Mech 53(3): 405-414, 2013.
doi: 10.1007/s11340-012-9644-y. PMID: n/a.

Hyland LL, Twomey JD, Vogel S, Hsieh AH, Yu YB. “Enhancing biocompatibility of D-oligopeptide hydrogels by negative charges.” Biomacromolecules 14(2): 406-412, 2013. doi: 10.1021/bm301598g. PMID: 23256640.

Golden RD, Kim H, Watson JD, Oliphant BW, Hawks M, Doro CJ, Hsieh AH, Osgood GM, O’Toole RV. “How much vertical displacement of the symphysis indicates instability after pelvic injury?” J Trauma Acute Care Surg 74(2): 585-589, 2013. doi: 10.1097/TA.0b013e31827d60f8. PMID: 23354255.

Oliphant BW, Kim H, Osgood GM, Golden RD, Hawks MA, Hsieh AH, O’Toole RV. “Pre-drilling does not improve pullout force in external fixator pins.” J Orthop Trauma 27(2): e25-30, 2013. doi: 10.1097/BOT.0b013e3182511ed7. PMID: 22495530.

Argintar E, Martin BD, Singer A, Hsieh AH, Edwards SG. “A biomechanical comparison of multidirectional nail and locking plate fixation in unstable olecranon fractures.” J Shoulder Elbow Surg 21(10): 1398-1405, 2012.doi: 10.1016/j.jse.2011.08.068. PMID: 22154306.

Edwards SG, Martin BD, Fu RH, Gill JM, Nezhad MK, Orr JA, Ferrucci AM, Fraser J, Singer A, Hsieh AH. “Quantifying and comparing torsional strains after olecranon plating.” Injury 43(6): 712-717, 2012. doi: 10.1016/j.injury.2011.06.417. PMID: 22348953.

Forward DP, Doro CJ, O’Toole RV, Kim H, Floyd JCP, Sciadini MF, Turen CH, Hsieh AH, Nascone JW. “Can a locking plate outperform a cephalomedullary nail in subtrochanteric femur fractures?” J Orthop Trauma 26(6): 334-340, 2012. doi: 10.1097/BOT.0b013e3182254ea3. PMID: 22241399.

Davis C, Stall A, Knutsen E, Whitney A, Becker E, Turen CH, Hsieh AH, O’Toole RV. “Locking plates in osteoporosis: a biomechanical cadaveric study of diaphyseal humerus fractures.” J Orthop Trauma 26(4): 216-221, 2012.  doi: 10.1097/BOT.0b013e318220edae. PMID: 22068207.

Hwang D, Gabai AS, Yu M, Yew AG, Hsieh AH. “Role of load history in intervertebral disc mechanics and intradiscal pressure generation.” Biomech Modeling Mechanobiol 11(1-2): 95-106, 2012. doi: 10.1007/s10237-011-0295-1. PMID: 21380846.

Walker M, Kim H, Hsieh AH, O’Toole RV, Eglseder A. “Do distal radius locking plates change articular contact pressures?” J Hand Surg Am 36A(8): 1303-1309, 2011. doi: 10.1016/j.jhsa.2011.05.015. PMID: 21719211.

Edwards SG, Martin BD, Orr JA, Fu R, Gill J, Ferruci A, Love JM, Booth R, Hsieh AH. “Comparison of olecranon plate fixation in osteoporotic bone: do current technologies and designs make a difference?” J Orthop Trauma 25(5): 306-311, 2011. doi: 10.1097/BOT.0b013e3181f22465. PMID: 21464739.

Shahmirzadi D, Hsieh AH. “Tissue and microstructural deformations in aortic tissue under stretch and after deformation recovery.” Mech Time-Depend Mater 15(1): 105-117, 2011. doi: 10.1007/s11043-010-9127-4. PMID: n/a.

Wang P, Li Y, Hsieh AH. “Nucleus pulposus cell response to confined and unconfined compression implicates mechanoregulation by fluid shear stress.” Ann Biomed Eng 39(3): 1101-1111, 2011. doi: 10.1007/s10439-010-0221-1. PMID: 21132369.

Hsieh AH, Yoon ST. “Update on the pathophysiology of degenerative disc disease and new developments in treatment strategies.” Open Access J Sports Med 1: 191-199, 2010. doi: 10.2147/OAJSM.S9057. PMID: n/a.

Doro CJ, Forward DP, Kim H, Nascone JW, Sciadini MF, Hsieh AH, Osgood G, O’Toole RV. “Does 2.5 cm of symphyseal widening differentiate anteroposterior compression I from anteroposterior compression II pelvic ring injuries?” J Orthop Trauma 24(10): 610-615, 2010. doi: 10.1097/BOT.0b013e3181cff42c. PMID: 20871248.

*Vigfusdottir A, *Pasrija C, Thakore PI, Schmidt RB, Hsieh AH. “Role of the cytoskeleton and pericellular matrix on mesenchymal stem cell deformation during chondrogenesis.” Cell Mol Bioeng 3(4): 387-397, 2010. doi: 10.1007/s12195-010-0135-x. PMID: n/a.

Shahmirzadi D, Hsieh AH. “An efficient technique for adjusting and maintaining specific hydration levels in soft biological tissues in vitro.” Med Eng Phys 32(7): 795-801, 2010. doi: 10.1016/j.medengphy.2010.04.021. PMID: 20678998.

Hsieh AH, Twomey JD. “Cellular mechanobiology of the intervertebral disc: new directions and approaches.” J Biomech 43(1): 137-145, 2010. doi: 10.1016/j.jbiomech.2009.09.019. PMID: 19828150.

Floyd JC, O'Toole RV, Stall A, Forward DP, Nabili M, Shillingburg D, Hsieh AH, Nascone JW. “Biomechanical comparison of proximal locking plates and blade plates for the treatment of comminuted subtrochanteric femoral fractures.” J Orthop Trauma 23(9): 628-633, 2009. doi: 10.1097/BOT.0b013e3181b04835. PMID: 19897983.

Rastogi A, Thakore P, Leung A, Benavides M, Machado M, Morschauser MA, Hsieh AH.
“Environmental regulation of notochordal gene expression in nucleus pulposus cells.” J Cell Physiol 220(3): 698-705, 2009. doi: 10.1002/jcp.21816. PMID: 19472213.

Hsieh AH, Hwang D, Ryan DA, Freeman AK, Kim H. “Degenerative anular changes induced by puncture are associated with insufficiency of disc biomechanical function.” Spine 34(10): 998-1005, 2009. doi: 10.1097/BRS.0b013e31819c09c4. PMID: 19404174.

Haudenschild AK, Hsieh AH, Kapila S, Lotz JC. “Pressure and distortion regulate human mesenchymal stem cell gene expression.” Ann Biomed Eng 37(3): 492-502, 2009. doi: 10.1007/s10439-008-9629-2. PMID: 19125331.

Nesson S, Yu M, Zhang X, Hsieh AH. “Miniature fiber optic pressure sensor with composite polymer-metal diaphragm for intradiscal pressure measurements.” J Biomed Opt 13(4): 044040, 2008. doi: 10.1117/1.2967908. PMID: 19021367.

Lotz JC, Hadi T, Bratton C, Reiser KM, Hsieh AH. “Anulus fibrosus tension inhibits degenerative structural changes in lamellar collagen.” Eur Spine J 17(9): 1149-1159, 2008. doi: 10.1007/s00586-008-0721-y. PMID: 18668268.

Nesson S, Yu M, Hsieh AH. “A miniature fiber optic pressure sensor for intervertebral disc pressure measurements of rodents.” Proc SPIE Nanosens Microsens Biosens Sys 6528: U180-U188, 2007. doi: 10.1117/12.715240.

Hsieh AH, Wagner DR, Cheng LY, Lotz JC. “Dependence of mechanical behavior of the murine tail disc on regional material properties: a parametric finite element study.” ASME J Biomech Eng 127(7): 1158-1167, 2005. doi: 10.1115/1.2073467. PMID: 16502658.

McKean JM, Hsieh AH, Sung KLP. “Epidermal growth factor differentially affects integrin-mediated adhesion and proliferation of ACL and MCL fibroblasts.” Biorheology 41(2): 139-152, 2004. PMID: 15090682.

Lotz JC, Staples A, Walsh A, Hsieh AH. “Mechanobiology in intervertebral disc degeneration and regeneration.” Proc IEEE Eng Med Biol Soc 7: 5459, 2004. doi: 10.1109/IEMBS.2004.1404528. PMID: 17271585.

Hsieh AH, Lotz JC. “Prolonged spinal loading induces matrix metalloproteinase-2 activation in intervertebral discs.” Spine 28(16): 1781-1788, 2003. doi: 10.1097/01.BRS.0000083282.82244.F3. PMID: 12923463.

Lotz JC, Hsieh AH, Walsh AL, Palmer EI, Chin JR. “Mechanobiology of the intervertebral disc.” Biochem Soc Trans 30(Pt 6): 853-858, 2002. doi: 10.1042/BST0300853. PMID: 12440932.

Hsieh AH, Sah RL, Sung KLP. “Biomechanical regulation of type I collagen gene expression in ACLs in organ culture.” J Orthop Res 20(2): 325-331, 2002. doi: 10.1016/S0736-0266(01)00112-7. PMID: 11924646.

Hsieh AH, Tsai CM, Ma QJ, Lin T, Banes AJ, Villarreal FJ, Akeson WH, Sung KLP. “Time-dependent increases in type-III collagen gene expression in medical collateral ligament fibroblasts under cyclic strains.” J Orthop Res 18(2): 220-227, 2000. doi: 10.1002/jor.1100180209. PMID: 10815822.

Yang L, Tsai CM, Hsieh AH, Lin VS, Akeson WH, Sung KLP. “Adhesion strength differential of human ligament fibroblasts to collagen types I and III.” J Orthop Res 17(5): 755-762, 1999. doi: 10.1002/jor.1100170521. PMID: 10569488.

Sung KLP, Yang L, Whittemore DE, Shi Y, Jin G, Hsieh AH, Akeson WH, Sung LA. “The differential adhesion forces of anterior cruciate and medial collateral ligament fibroblasts: effects of tropomodulin, talin, vinculin, and alpha-actinin.” Proc Natl Acad Sci U S A 93(17): 9182-9187, 1996. doi: n/a. PMID: 8799175.

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