Faculty Directory

Bentley, William E.

Bentley, William E.

Robert E. Fischell Distinguished Professor
Director, Robert E. Fischell Institute for Biomedical Devices
Fischell Department of Bioengineering
Chemical and Biomolecular Engineering
3122 Jeong H. Kim Engineering Building

EDUCATION

Ph.D., University of Colorado at Boulder, 1989

BACKGROUND

William E. Bentley is the Robert E. Fischell Distinguished Professor of Engineering and founding Chair of the Fischell Department of Bioengineering. He is also appointed to the Department of Chemical and Biomolecular Engineering at the University of Maryland, College Park and the Institute for Bioscience and Biotechnology Research. At Maryland since 1989, Dr. Bentley has focused his research on the development of molecular tools that facilitate the expression of biologically active proteins, having authored over 250 related archival publications. Recent interests are on deciphering and manipulating signal transduction pathways, including those of bacterial communication networks, for altering cell phenotype. To enable discovery, his lab develops new strategies for opening ‘communication’ between devices and biological systems by the creation and facile assembly of biologically functional interfaces. These concepts are emerging as a field of ‘biofabrication’ that exploits biological components and processes for assembly. He has served on advisory committees for the NIH, NSF, DOD, DOE, FDA, USDA, and several state agencies. He has mentored more than 30 PhDs and 15 postdocs, many now in leadership roles within industry (18), federal agencies (4) and academia (22).  He co-founded a protein manufacturing company, Chesapeake PERL, based on insect larvae as mini bioreactors. Dr. Bentley was recipient of the SIM’s Schering-Plough Young Investigator Award, the Charles Thom Award of the SIMB, and the AIChE’s FPB Division Award. He is also a Fellow of the ACS, AAAS, and AIMBE and is an elected member of the American Academy of Microbiology. 

HONORS AND AWARDS

For the complete list, please visit Professor Bentley's web site

  • Charles Thom Award, Society of Industrial Microbiology and Biotechnology (2013)
  • Elected Fellow, American Chemical Society (ACS) (2013)
  • Elected Member, Electorate Nominating Committee, American Association for the Advancement of Science (2013)
  • Meeting Keynote, Upstream Processing, BIOT Division of American Chemical Society’s 245th National Meeting, New Orleans (2013)
  • AIChE Food, Pharmaceutical and Bioengineering Division Award in Chemical Engineering (2012)
  • University System of Maryland (USM) Regents’ Faculty Award for Research/Scholarship/Creative Activity (2011)
  • Robert E. Fischell Distinguished Professor (current)
  • Herbert Rabin Distinguished Professor (former)
  • Fellow, American Academy of Microbiology (AAM) (2007)
  • Fellow, American Association for the Advancement of Science (2001)
  • Fellow, American Institute for Medical and Biological Engineering (2001)
  • Maryland's Outstanding Young Engineer, Maryland Science Center (1998)
  • Washington Academy of Sciences Allen C. Davis Medal (1998)
  • Schering-Plough Young Investigator Award (1996)
  • Dow Outstanding New Faculty Award from the American Society for Engineering Education (1995)
  • Society of Industrial Microbiology Outstanding Achievement in Engineering Sciences Award

PROFESSIONAL MEMBERSHIPS

  • American Academy of Microbiology
  • American Association for the Advancement of Science
  • American Chemical Society
  • American Institute of Chemical Engineers
  • American Institute for Medical and Biological Engineering
  • Biomedical Engineering Society

Biomolecular and metabolic engineering; cell-cell communication; heterologous protein expression; device/bio interfaces.

  • Metabolic and Biomolecular Engineering - Quorum Sensing and in vivo Genetic Manipulation
  • Biofabrication Engineering of Biological Signaling (bBIOS)
  • Bridging the communication gap between biology and electronics through the use of redox molecules
  • Characterization of AI-2 uptake in E. coli quorum sensing circuitry
  • Development of a generic strategy for the covalent assembly of proteins onto patterned surfaces, including sensor surfaces

For more information, please visit Professor Bentley's web site and the Biochip Collaborative

For a complete list of publications, please visit Professor Bentley's web site

Terrell J.L., Wu H.C., Tsao C.Y., Barber N.B., Servinsky M.D., Payne G.F., and Bentley W.E. (2015) Nano-guided cell networks as conveyors of molecular communication, Nature Communications, doi: 10.1038/ncomms9500.

Payne, G.F., Kim, E., Cheng, Y., Wu, H-C., Ghodssi, R., Rubloff, G.W., Raghavan, S.R., Culver, J.N, and W.E. Bentley (2013) Accessing Biology’s Toolbox for the Mesoscale Biofabrication of Soft Matter, Soft Matter, doi:10.1039/c3sm50527h.
 
Bacalocostantis, I., Mane, V.P., Goodley, A.S., Bentley, W.E., Muro, S., and P. Kofinas (2013) Investigating Polymer Thiolation in Gene Delivery, J. Biomaterials Science and Polymer Ed, 24(8):912-926.
 
Betz, J.F., Cheng, Y., Tsao, C.-Y., Zargar, A., Luo, X, Payne, G.F., Bentley, W.E., and G.W. Rubloff (2013) Optically Clear Alginate Hydrogels for Spatially Controlled Cell Entrapment and Culture at Microfluidic Electrode Surfaces. Lab on a Chip, 13(10): 1854-1858.
 
Kim, E., Gordonov, T., Bentley, W. E., and G.F. Payne (2013) Amplified and in situ detection of redox-active metabolite using a biobased redox capacitor, Analytical Chemistry 85, 2102-2108.
 
Kim, E., Gordonov, T., Liu, Y., Bentley, W. E., and G. F. Payne (2013) Reverse engineering to suggest biologically relevant redox activities of phenolic materials, ACS Chemical Biology 8, 716-724.
 
Liba, B. D., Kim, E., Martin, A. N., Liu, Y., Bentley, W. E., and G.F. Payne (2013) Biofabricated film with enzymatic and redox-capacitor functionalities to harvest and store electrons, Biofabrication 5, 015008.
 
Liu, Y., B. Zhang, K. M. Gray, Y. Cheng, E. Kim, G. W. Rubloff, W. E. Bentley, Q. Wang, G. F. Payne (2013) Electrodeposition of a Weak Polyelectrolyte Hydrogel: Remarkable Effects of Salt on Kinetics, Structure and Properties. Soft Matter, 9; 2703-2710.

Gupta, A., Terrell, J.L., Fernandes, R., Dowling, M.B., Payne, G.F., Raghavan, S.R., and W.E. Bentley (2013) Encapsulated Fusion Protein Confers “Sense and Respond” Activity to Chitosan-Alginate Capsules to Manipulate Bacterial Quorum Sensing. Biotechnology and Bioengineering, 110, 552-562.
 
Payne, G.F., E. Kim, Y. Cheng, H-C. Wu, R. Ghodssi, G.W. Rubloff, S.R. Raghavan, J.N. Culver, and W.E. Bentley. (2013) Accessing Biology's Toolbox for the Mesoscale Biofabrication of Soft Matter. Soft Matter, 9, 6019-6032.
 
Wu, H.-C., Hebert, C.G., Hung, C.-W., Quan, D.N., Carter, K.K., and W.E. Bentley (2013) Tuning Cell Cycle of Insect Cells for Enhanced Protein Production. Journal of Biotechnology, 10.1016/j.biotec.2013.08.017.
 
Wu, H. C., Tsao, C. Y., Quan, D. N., Cheng, Y., Servinsky, M. D., Carter, K. K., Jee, K. J., Terrell, J. L., Zargar, A., Rubloff, G. W., Payne, G. F., Valdes, J. J., and  W.E. Bentley (2013) Autonomous bacterial localization and gene expression based on nearby cell receptor density, Molecular Systems Biology 9, 636.
 
Bentley, W.E., and G.F. Payne (2013) Nature’s Other Self-Assemblers, Science, 341(6142): 136-137.

Carter, K.K., Valdes, J.J., and W.E. Bentley (2012) Pathway Engineering via Quorum Sensing and sRNA Riboregulators – Interconnected Networks and Controllers, Metabolic Engineering, 14(3): 281-288.

Terrell, J.L., Gordonov, T., Cheng, Y., Wu, H.C., Sampey, D., Luo, X., Tsao, C.Y., Ghodssi, R., Rubloff, G.W., Payne, G.F., and W.E. Bentley (2012) Integrated Biofabrication for Electro-Addressed In-Film Bioprocessing, Biotechnology Journal, 7(3):428-439.
 
Cheng, Y., Tsao, C.-Y., Wu, H.-C., Luo, X.L., Terrell, J.L., Betz, J., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2012) Electroaddressing Functionalized Polysaccharides as Model Biofilms for Interrogating Cell Signaling, Advanced Functional Materials, 22(3):519-528.
 
Liu, Y., Terrell, J.L., Tsao, C.-Y., Wu, H.C., Jawaji, V., Kim, E., Cheng, Y., Wang, Y.F., Ulijn, R.V., Raghavan, S.R., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2012) Biofabricating Multifunctional Soft Matter with Enzymes and Stimuli-Responsive Materials, Advanced Functional Materials, 22(14):3004-3012.
 
Luo, X.L., Wu, H.C., Tsao, C.-Y., Cheng, Y., Betz, J., Payne, G.F., Rubloff, G.W., and W.E. Bentley (2012) Biofabrication of Stratified Biofilm Mimics for Observation and Control of Bacterial Signaling, Biomaterials, 33(20): 5136-5143.
 
Gamby, S., Roy, V., Guo, M., Smith, J.A.I., Wang, J.X., Stewart, J.E., Wang, X., Bentley, W.E., and H.O. Sintim (2012) Altering the Communication Networks of Multispecies Microbial Systems Using a Diverse Toolbox of AI-2 Analogues, ACS Chemical Biology, 7(6):1023-1030.
 
Kim, E., Liu, Y., Bentley, W.E., and G.F. Payne (2012) Redox Capacitor to Establish Bio-Device Redox-Connectivity, Advanced Functional Materials, 22(7):1409-1416.
 
Gray, K. M., B. D. Liba, Y. Wang, Y. Cheng, G. W. Rubloff, W. E. Bentley, A. Montembault, I. Royaud, L. David, G. F. Payne (2012) Electrodeposition of a Biopolymeric Hydrogel: Potential for One-step Protein Electroaddressing. Biomacromolecules, 13(4), 1181-1189.

Gordonov, T., Liba, B., Terrell, J.L., Cheng, Y., Luo, X., Payne, G.F. and W.E. Bentley (2012) Bridging the Bio-electronic Interface with Biofabrication, Journal of Visualized Experiments, doi:10.379/4321.
 
Liu, Y., V. Javvaji, S. R. Raghavan, W. E. Bentley, G. F. Payne (2012) Glucose Oxidase Mediated Gelation: A Simple Test to Detect Glucose in Food Products. Journal of Agricultural and Food Chemistry, 60(36):8963-8967.
 
Cheng, Y., Luo, X.L., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2012) Biofabrication: Programmable Assembly of polysaccharide hydrogels in microfluidics as biocompatible scaffolds. J. Mater. Chem. 22(16), 7659-7666.
 
Kim, Y.W., Sardari, S.E., Meyer, M.T., Iliadis, A.A., Wu, H.C., Bentley, W.E., and R. Ghodssi (2012) An ALD Aluminum Oxide Passivated Surface Acoustic Wave Sensor for Early Biofilm Detection. Sensors and Actuators B 163:136-145.
 
Quan, D., W.E. Bentley (2012) Gene Network Homology in Prokaryotes Using a Similarity Search Approach: Queries of Quorum Sensing Signal Transduction. PLoS Computational Biology. E1002637.

Ben-Yoav, H., Dykstra, P.H., Bentley, W.E., and R. Ghodssi. (2012) A Microfluidic-based Electrochemical Biochip for Label-free Diffusion-restricted DNA Hybridization Analysis. Biosensors and Bioelectronics, 38(1):114-120.
 
Roy, V., Meyer, M.T., Smith, J.A., Gamby, S., Sintim, H.O., Ghodssi, R., and W.E. Bentley (2012) AI-2 Analogs and Antibiotics: A Synergistic Approach to Reduce Bacterial Biofilms. Applied Microbiology and Biotechnology, (10.1007/s00253-012-4404-6).
 
Tsao, C.-Y., Quan, D.Q. and W.E. Bentley (2012) Development of the Quorum Sensing Biotechnological Toolbox. Current Opinion in Chemical Engineering, DOI: 10.1016/j.coche.2012.09.008.
 
Liu, Y., J. L. Terrell, C.-Y. Tsao, H.-C. Wu, V. Javvaji, E. Kim, Y. Cheng, Y. Wang, R. V. Ulijn, S. R. Raghavan, G. W. Rubloff, W. E. Bentley, G. F. Payne. (2012) Biofabricating Multi-functional Soft Matter with Enzymes and Stimuli-Responsive Materials. Advanced Functional Materials, doi: 10.1371/journal.pcbi.1002637.

Tsao, C.Y., Hooshangi, S., Wu, H.C., Valdes, J.J., and W.E. Bentley (2010) Autonomous Induction of Recombinant Proteins by Minimally Rewiring Native Quorum Sensing Regulon of E. coli, Metabolic Engineering, 12(3):291-297.

Terrell, J.L., Gordonov, T., Cheng, Y., Wu, H.C., Sampey, D., Luo, X., Tsao, C.Y., Ghodssi, R., Rubloff, G.W., Payne, G.F., and W.E. Bentley (2011) Integrated Biofabrication for Electro-Addressed In-Film Bioprocessing, Biotechnology Journal, (Epub, PMID 22213675).

Carter, K.K., Valdes, J.J., and W.E. Bentley (2011) Pathway Engineering via Quorum Sensing and sRNA Riboregulators – Interconnected Networks and Controllers, Metabolic Engineering, (Epub, PMID22155614).

Luo, X.L., Buckhout-White, S., Bentley, W.E., and G.W. Rubloff (2011) Biofabrication of Chitosan-Silver Composite SERS Substrates Enabling Quantification of Adenine by a Spectroscopic Shift, Biofabrication, 3(3):034108.

Cheng, Y., Luo, X., Tsao, C.-Y., Wu, H.C., Betz, J., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2011) Biocompatible multi-address 3D Cell Assembly in Microfluidic Devices Using Spatially Programmable Gel Formation, Lab on a Chip, 11(14):2316-2318.

Kamaraju, K., Smith, J., Wang, J., Roy, V., Sintim, H.O., Bentley, W.E., and S. Sukharev (2011) Effects on Membrane Lateral Pressure Suggest Permeation Mechanisms for Bacterial Quorum Sensing Molecules, Biochemistry, 50(32):6983-93.

Wang, Y., Liu, Y., Cheng, Y., Kim, E., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2011) Coupling Electrodeposition with Layer-by-Layer Assembly to Address Proteins within Microfluidic Channels, Advanced Materials, 23(8):5817-5821

Hooshangi, S., and W.E. Bentley (2011) LsrR Quorum Sensing “Switch” is Revealed by a Bottom-up Approach, PLoS Computational Biology, 7(9):e1002172.

Dykstra, P.H., Roy, V., Byrd, C., Bentley, W.E., and R. Ghodssi (2011) Microfluidic Electrochemical Sensor Array for Characterizing Protein Interactions with Various Functionalized Surfaces, Analytical Chemistry, 83(15):5920-5927.Dykstra, P.H., Roy, V., Byrd, C., Bentley, W.E., and R. Ghodssi (2011) Microfluidic Electrochemical Sensor Array for Characterizing Protein Interactions with Various Functionalized Surfaces, Analytical Chemistry, 83(15):5920-5927.

Roy, V., Adams, B.L., and W.E. Bentley (2011) Developing Next Generation Antimicrobials by Intercepting AI-2 Mediated Quorum Sensing, Enzyme and Microbial Technology, 49(2): 113-123.

Liu, Y., Yi, C., Wu, H.C., Kim, E., Ulijn, R.V., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2011) Electroaddressing Agarose Using Fmoc-Phenylalanine as a Temporary Scaffold, Langmuir, 27(12):7380-7384.

Liu, Y., Kim, E., Ulijn, R.V., Bentley, W.E., and G.F. Payne (2011) Reversible Electroaddressing of Self-assembling Amino-Acid Conjugates, Advanced Functional Materials, 21(9):1575-1580.

Meyer, M.T., Roy, V., Bentley, W.E., and R. Ghodssi (2011) Development and Validation of a Microfluidic Reactor for Biofilm Monitoring via Optical Methods, Journal of Micromechanics and Microengineering, 21(5) (#054023).

Tsao, C.Y., Wang, L., Hashimoto, Y., Yi, H., March, J.C., Delisa, M.P., Wood, T.K., Valdes, J.J., and W.E. Bentley (2011) LuxS Co-expression Enhances Yield of Recombinant Proteins in E. coli in part through Post-transciptional control of GroEL. Applied and Environmental Microbiology, 77(6):2141-2152.

Liu, Y., Shi, X.W., Kim, E., Robinson, L.M., Nye, C.K., Ghodssi, R., Rubloff, G.W., Bentley, W.E., and G.F. Payne (2011) Chitosan to Electroaddress Biological Components in Lab-on-a-Chip Devices, Carbohydrate Polymers, 84(2):704-708.

Wu, L.Q., Bentley, W.E., and G.F. Payne (2011) Biofabrication with biopolymers and enzymes: Potential for constructing scaffolds from soft matter, International Journal of Artificial Organs, (E-Pub).

Kim, E., Liu, Y., Baker, C.J., Owens, R., Xiao, S., Bentley, W.E., and G.F. Payne (2011) Redox-cycling and H(2)O(2) Generation by Fabricated Catecholic Films in the Absence of Enzymes, Biomacromolecules, 12(4):880-888.

Gray, K.M., Kim, E., Wu. L-Q., Liu, Y., Bentley, W.E., and G.F. Payne (2011) Biomimetic Fabrication of Information-Rich Phenolic-Chitosan Films, Soft Matter, 7(20):9601-9615.

Cheng, Y., Luo, X., Betz, J., Payne, G.F., Bentley, W.E., and G.W. Rubloff (2011) Mechanism of Anodic Electrodeposition of Calcium Alginate, Soft Matter, 7(12), 5677-5684.

Fernandes, R., Roy, V., Wu, H.C., and W.E. Bentley (2010) Engineered biological nanofactories trigger quorum sensing response in targeted bacteria, Nature Nanotechnology, 5(3)213-217.

Fernandes R., Luo, X., Tsao, C.-Y., Payne, G.F., Ghodssi, R., Rubloff, G.W., and W.E. Bentley (2010) Biological Nanofactories Facilitate Spatially Selective Capture and Manipulation of Quorum-Sensing Bacteria in a BioMEMS Device, Lab on a Chip, 10(9):1128-1134.

Roy, V., Fernandes, R., Tsao, C.Y., and W.E. Bentley (2010) Cross Species Quorum Quenching Using A Native AI-2 Processing Enzyme, ACS Chemical Biology, 5(2):223-232.

Koev, S.T., Bentley, W.E., Ghodssi, R (2010) Interferometric readout of multiple cantilever sensors in liquid samples, Sensors and Actuators B–Chemical, 146(1):245-252.

Yang, X.H., Kim, E., Liu, T., Shi, X.W., Rubloff, G.W., Ghodssi, R., Bentley, W.E., and G.F. Payne (2010) In-film Bioprocessing and Immunoanalysis with Electroaddressable Stimuli-Responsive Polysaccharides, Advanced Functional Materials, 20(10):1645-1652.

Liu, Y., Kim, E., Ghodssi, R., Rubloff, G.W., Culver, J.N., Bentley, W.E., and G.F. Payne (2010) Biofabrication to Build the Biology-Device Interface, Biofabrication, 2(2):220.

Kim, E., Liu, Y., Shi, X.W., Yang, X., Bentley, W.E., and G.F. Payne (2010) Biomimetic Approach to Confer Redox Activity to Thin Chitosan Films, Advanced Functional Materials, (in press).

Roy, V., Smith, J.A., Wang, J., Stewart, J.E., Bentley, W.E., and H.O. Sintim (2010) Synthetic Analogs Tailor AI-2 Signaling Across Bacterial Species, Journal of the American Chemical Society, (online).

Bauer, R.I., Luo, X., and W.E. Bentley (2010) Chips & Tips: Customizable PDMS Chamber for Cell Imaging, Lab on a Chip, (in press).

Hebert, C., Gupta, A., Tsao, C-Y., Valdes, J.J., and W.E. Bentley (2010) Biological Nanofactories target and Activate Epithelial Cell Surfaces for Modulating Bacterial Quroum Sensing and Interspecies Signaling, ACS Nano, (e pub).

Lee, J., Bansal, T., Jayaraman, A., Bentley, W.E., and T.K. Wood (2007) Enterohemorrhagic Escherichia coli Biofilms are Inhibited by 7-Hydroxyindole and Stimulated by Isatin, Applied and Environmental Microbiology.

Yung, C.W., Tullman, J.A., Payne, G.F., Bentley, W.E., and T.A. Barbari (2007) Transglutaminase Crosslinked Gelatin as a Tissue Engineering Scaffold, Journal of Biomedical Materials Research A, (Epub ahead of print).

Li, J., Attila, C., Wang, L., Wood, T.K., Valdes, J.J., and W.E. Bentley (2007) Quorum Sensing in E. coli is Signaled by AI-2/LsrR: Effects on sRNA and Biofilm Architecture, Journal of Bacteriology, 73:4100-4109.

Fernandes, R., Tsao, C.Y., Hashimoto, Y., Wang, L., Wood, T.K., Payne, G.F., and W.E. Bentley (2007) Magnetic Nanofactories: Localized Synthesis and Delivery of Quorum-Sensing Signaling Molecule Autoinducer-2 to Bacterial Cell Surfaces, Metabolic Engineering, 9:228-239.

Small, D.A., Chang, W., Bentley, W.E., and F. Toghrol (2007) Toxicogenomic Analysis of Sodium Hypochlorite Antimicrobial Mechanisms in Pseudomonas aeruginosa, Applied Microbiology and Biotechnology, 74:176-185.

Kim, E.J., Kramer, S.F., Hebert, C.G., Valdes, J.J., and W.E. Bentley (2007) Metabolic Engineering of the Baculovirus-Expression System via Inverse "Shotgun" Genomic Analysis & RNA Interference (dsRNA) Increases Product Yield and Cell Longevity, Biotechnology and Bioengineering, 98:645-654.

March, J.C., and W.E. Bentley (2007) RNAi-based Tuning of Cell Cycling in Drosophila S2 cells- effects on Recombinant Protein Yield, Applied Microbiology and Biotechnology, 73: 1128-1135.

Koev, S.T., Powers, M. A. Powers, Yi, H.M., Wu, L-Q., Bentley, W.E., Rubloff, G.W., Payne, G.F., and R. Ghodssi, (2007) Mechano-transduction of DNA Hybridization and Dopamine Oxidation through Electrodeposited Chitosan Network, Lab on a Chip, 7:103-111.

Small, D.A, Chang, W., Toghrol, F., and W.E. Bentley (2007) Comparative Global Transcription Analysis of Sodium Hypochlorite, Peracetic Acid, and Hydrogen Peroxide on Pseudomonas aeruginosa, Applied Microbiology and Biotechnology, 76:1093-1105.

O’Connell, K.P., Kovaleva, E., Campbell, J.H., Anderson, P.E., Brown, S.G., Davis, D.C., Valdes, J.J., Welch, R.W., Bentley, W.E. and N.A. van Beek (2007) Production of a Recombinant Antibody Fragment in Whole Insect Larvae, Molecular Biotechnology, 36:44-51.

Hung, C-W., Holoman, T.R.P., Kofinas, P., and W.E. Bentley (2007) Towards Oriented Assembly of Proteins onto Magnetic Nanoparticles, Biochemical Engineering Journal.

Saini, S.S., Stanford, C., Lee, S.M., Park, J., DeShong, P., Bentley, W.E., and M. Dagenais (2007) Monolayer Detection of Biochemical Agents Using Etched-Core Fiber Bragg Grating Sensors, IEEE Photonics Technology Letters, 19:1341-1343.

Lewandowski, A.T., Yi, H., Luo, X., Payne, G.F., Ghodssi, R., Rubloff, G.W., and W.E. Bentley (2007) Protein Assembly onto Patterned Microfabricated Devices through Enzymatic Activation of Fusion Pro-tag. Biotechnology and Bioengineering.

March, J.C., and W.E. Bentley (2007) Methods for gene silencing with RNAi, Methods in Molecular Biology, 388:424-434.

Hu, Y.C., and W.E. Bentley (2007) Alternative Bioreactor Strategy for Probing Infection and Production, Methods in Molecular Biology, 388:419-426.

Cha, H.J., and W.E. Bentley (2007) Monitoring and Visualization of Baculovirus Infection Using Green Fluorescent Protein Strategy, Methods in Molecular Biology, 388:407-418.

Lewandowski, A.T., Small, D.A., Chen, T., Payne, G.F., and W.E. Bentley (2006) Tyrosine-based "activatable pro-tag": enzyme-catalyzed protein capture and release, Biotechnology and Bioengineering, 93:1207-1215.

Chang, W., Small, D.A., Toghrol, F., and W.E. Bentley (2006) Global Transcriptome Analysis of Staphylococcus aureus Response to Hydrogen Peroxide, Journal of Bacteriology, 188:1648-1659.

Gonzalez Barrios, A.F., Zuo R., Hashimoto, Y., Yang, L., Bentley W.E., and T.K. Wood (2006) Autoinducer 2 Controls Biofilm Formation in Escherichia coli Through a Novel Motility Quorum-sensing Regulator (MqsR, B3022), Journal of Bacteriology, 188:205-316.

Bleckwenn, N. A. and Bentley, W.E. (2006) Systems and Technology Involving Bacteria, In CRC BME Handbook: Tissue Engineering and Artificial Organs (JD Bronzino, ed.) CRC Press, Boca Raton, FL, 2.1-2.10.

Yung, C., Barbari, T.A., and W.E. Bentley (2006) Integrated Non-Invasive System for Quantifying Secreted Human Therapeutic hIL2, Biotechnology and Bioengineering.

Yang, L., Portugal, F.H., and W.E. Bentley (2006) Conditioned Medium from Listeria innocua Stimulate Emergence from a Resting State not in Response to Quorum Sensing Autoinducer AI-2, Biotechnology Progress, 22:387-393.

March, J.C., and W.E. Bentley (2006) Engineering Eukaryotic Signal Transduction with RNAi: Enhancing Drosophila S2 Cell Growth and Recombinant Protein Synthesis via Silencing of TSC1. Biotechnology and Bioengineering.

Park, J.J., Valentine, T.M., Yi, H., Payne, G.F., Bentley, W.E., Ghodssi, R., and Gary W. Rubloff (2006) In situ Biomolecule Assembly in Completely Packaged Microfluidic Devices, Lab on a Chip.

Yung, C.W., Barbari, T.A., and W.E. Bentley (2006) Counteracting Apoptosis and Necrosis with Hypoxia Responsive Expression of Bcl-2D, Metabolic Engineering.

Cresce, A.V., Silverstein, J.S., Bentley, W.E., and P. Kofinas (2006) Nanopatterning of Recombinant Proteins using Block Copolymer Templates, Macromolecules, 39, 5826-5829.

Dalal, N.G., Cha, H.J., Kramer, S.F., Kostov, Y., Rao, G. and W.E. Bentley (2006) Rapid Non-invasive Monitoring of Baculovirus Infection for Insect Larvae Using Green Fluorescent Protein Reporter Under Early-to-Late Promoter and a GFP-Specific Optical Probe, Process Biochemistry, 41:947-950.

Li, J., Wang, L., Hashimoto, Y., Tsao, C-Y., Wood, T.K., Valdes, J.J., Zafiriou, E., and W.E. Bentley (2006) Stochastic Model of E. coli AI-2 Quorum Signal Circuit Reveals Alternative Synthesis Pathways, Nature Molecular Systems Biology.

Wang, L., Hashimoto, Y., Tsao, C.-Y., Valdes, J.J., and W.E. Bentley (2005) cAMP and cAMP Receptor Protein (CRP) Influence Both  Synthesis and Uptake of Extracellular Autoinducer-2 in Escherichia coli, Journal of Bacteriology, 187:2066-76.

Yi, H., Wu, L.Q., Rubloff, G.W., Ghodssi, R., Payne, G.F., and Bentley, W.E., (2005) Signal-Directed Sequential Assembly of Biomolecules on Patterned Surfaces. Langmuir, 2:2104-2107.

Tao, Y., Bentley, W.E., and T.K. Wood, (2005) Regiospecific Oxidation of Naphthalene and Fluorene by Toluene Monooxygenase and Engineered Toluene 4-Monooxygenase of Pseudomonas mendocina KR1, Biotechnology and Bioengineering, 90:85-94.

Cha, H.J., Shin, H.S., Lim, H.J., Cho, H.S., Dalal, N.N., Pham, M.Q., and W.E. Bentley (2005) Comparative Production of Human Interleukin-2 Fused with Green Fluorescent Protein in Several Recombinant Expression Systems, Biochemical Engineering Journal, 24:225-233.

Lu C.H., Albano C.R., Bentley W.E., and G. Rao (2005) Quantitative and kinetic study of oxidative stress Regulons using green fluorescent protein, Biotechnology and Bioengineering, 89: 574-587.

Bleckwenn, N. A., Bentley, W. E., Shiloach, J., (2005) Vaccinia Virus-Based Expression of gp120 and EGFP: Survey of Mammalian Host Cell Lines, Biotechnology Progress, 21:186-191.

Bleckwenn, N. A., Bentley, W. E., Shiloach, J., (2005) Evaluation of Production Parameters with the Vaccinia Virus Expression System Using Microcarrier Attached HeLa Cells, Biotechnology Progress, 21:554-561.

Bleckwenn, N. A., Bentley, W. E., Shiloach, J., (2005) Production of Recombinant Protein Using the HeLa S3-Vaccinia Virus Expression System: Bioreactor Perfusion and Effects of Post-Infection Temperature, Journal of Bioscience, Biotechnology and Biochemistry, 69:1065-1072.

Bleckwenn, N. A., Golding, H., Bentley, W. E., Shiloach, J., (2005) Production of Recombinant Proteins by Vaccinia Virus in a Microcarrier Based Mammalian Cell Perfusion Bioreactor, Biotechnology and Bioengineering, 90:663-674.

Tao, Y., Bentley, W.E., and Wood, T.K. (2005) Phenol and 2-Naphthol Production by Toluene 4-Monooxygenases Using an Aqueous/Dioctyl Phthalate system, Applied Microbiology & Biotechnology, 68:614-621. 

Dalal, N.G., Bentley, W.E., and H.J. Cha (2005) Facile Monitoring of Baculovirus Infection for Foreign Protein Expression under Very Late Polyhedrin Promoter using Green Fluorescent Protein Reporter under Early-to-Late Promoter, Biochemical Engineering Journal, 24:27-30.

Cha, H.J., Dalal, N.G., and Bentley, W.E. (2005) Secretion of Human Interleukin-2 Fused with Green Fluorescent Protein in Recombinant Pichia pastoris, Applied Biochemistry and Biotechnology, 126:1-11.

Powers, M.A., S. T. Koev, A. Schleunitz, H. Yi, V. Hodzic, W. E. Bentley, G. F. Payne, G. W. Rubloff, and R. Ghodssi (2005) Integrated Optical Sensing of Biofunctionalized Sites in BioMEMS, Lab on a Chip, 5:583-586.

Chryssis, A.N., Saini, S.S., Lee, S.M., Yi, H.M., Bentley, W.E., and M. Dagenais (2005) Detecting Hybridization of DNA by Highly Selective Evanescent Field Etched Core Fiber Bragg Grating Sensors, IEEE Journal of Selected Topics in Quantum Electronics, 11:864-872.

Chang, W., Small, D.A. Toghrol, F., and W.E. Bentley (2005) Microarray Analysis of Toxicogenomic Effects of Peracetic Acid on Pseudomonas aeruginosa, Environmental Science & Technology, 39:5893-5899.

Chang, W., Small, D.A., Toghrol, F., and W.E. Bentley (2005) Microarray Analysis of Pseudomonas aeruginosa Reveals Induction of Pyocin Genes in Response to Hydrogen Peroxide, BMC Genomics, 6.115-129.

Yi, H., Nisar, S., Lee, S.Y., Powers, M.A., Bentley, W.E., Payne, GF, Ghodssi, R., Rubloff, G.W., Harris, M.T., Culver, J.N. (2005) Patterned Assembly of Genetically Modified Viral Nanotemplates via Nucleic Acid Hybridization, Nano Letters, 5:1031-1936.

Wang, L., Li, J., March, J.C., Valdes, J.J., and W.E. Bentley (2005), luxS-Dependent Gene Regulation in Escherichia coli K-12 Revealed by Genomic Expression Profiling, Journal of Bacteriology, 187:8350-8360.

Yi, H., Wu, L.Q., Bentley, W.E., Ghodssi, R., Rubloff, G.W., Culver, J.N., Payne, G.F., (2005) Biofabrication with Chitosan, Biomacromolecules, 6:2881-2894.

FDA Awards $5 Million to Pediatric Device Consortium

National Capital Consortium co-led by Children's National and University of Maryland

M-CERSI Cooperative Agreement Grant Renewed by Food and Drug Administration

Latest renewal allows for up to $5 million per year over five years.

Bridging the Gap between Microelectronics, Biological Systems

UMD researchers receive $1.5 M NSF grant to develop first-of-kind bioelectronics.

New Findings Demonstrate How the Food We Eat Affects Biochemical Signals in the Gut

Research collaboration sheds light on bacteria response to sugar metabolism

Researchers Engineer Bacteria to Hunt Down Pathogens in the Gut

Nature Communications highlights University of Maryland alum’s latest efforts to program E.coli to combat infections.

Government, Industry, Academia Representatives Collaborate to Advance Medical Device Innovation in Maryland

Robert E. Fischell Institute for Biomedical Devices, RTI International draw capacity crowd to March 7th event.

UMD Key Partner in New National Institute for Innovation of Manufacturing Biopharmaceuticals

$250 million dollar investment will advance leadership in pharmaceutical manufacturing

Bentley Named Distinguished University Professor

Fischell Dept. of Bioengineering founding chair recognized with university's highest academic honor conferred upon faculty.

Fischell Receives National Medal of Technology and Innovation

UMD Alum, BioE Professor of Practice to Receive White House Honor

NCC-PDI Pediatric Device Competition Now Accepting Proposals From Medical Device Innovators

$250,000 to be awarded to five innovations at third annual National Capital Consortium for Pediatric Device Innovation (NCC-PDI) Competition.

Fisher Named Chair of the Fischell Department of Bioengineering

Dr. John P. Fisher to succeed Dr. William E. Bentley as department chair, effective Jan. 4, 2016.

BioE Capstone 2015: New Projects Focus on Sensorineural Hearing Loss, Injury Rehabilitation, and More

Neonatal acoustic protection device takes first place in annual design competition.

Bentley Featured in Science Update Podcast

Podcast focuses on bioengineers’ work creating bacteria that can act as smart drug delivery machines.

Bentley Contributes to The Scientist Report on Bacterial Signaling in the GI Tract

BioE Chair discusses how a bacterial signaling molecule could promote healthy gut microbiota.

Second Annual Pediatric Device Innovation Competition Awards $250,000

National Capital Consortium for Pediatric Device Innovation (NCC-PDI) recognizes five innovators.

UMD Researchers Bridge Gap between Microelectronics, Biological Systems

“Electronic modulation of biochemical signal generation” published in Nature Nanotechnology

BioE Capstone 2014: New Projects Focus on Cardiological Health, Surgical Tools and More

Students' inventions range from diagnostic devices to accident prevention products.

Bentley Receives ACS BIOT’s Marvin J. Johnson Award

American Chemical Society recognizes professor for contributions to the field of biotechnology.

Chung Honored at Commencement

Academic director receives Dr. Marilyn Berman Pollans Outstanding Service Award for Staff

Barber Awarded Olatunji Godo Biomedical Research Scholarship

Fund established by alumnus supports BioE junior.

BioE Holds 7th Fischell Festival (VIDEO)

Annual event highlights engineering's increasing role in medicine.

BioE's Chris Jewell Named Outstanding Young Engineer

Md. Science Center honors expert in controlling immune system response.

BioE and Mtech Partner with Children's National Health System to Form Pediatric Device Consortium

FDA-supported collaboration will focus on medical device design, production and regulation.

Bentley Comments on 3D-Printed Bacteria

Professor contributes thoughts on biofabrication to Chemistry World story.

BioE Hosts First Luojia International Biomedical Conference

Event fosters collaborations between UMD and Wuhan University.

Bacteria Prowl for Pathogen Prey

Alumnus Matthew Wook Chang's custom E. Coli target hospital-acquired infections.

Bentley Receives Charles Thom Award

Society for Industrial Microbiology and Biotechnology honors professor for contributions to the field.

Shapiro, Yu Win 2013 BioE Teaching, Graduate Research Awards

Honors presented at annual "Welcome Back" seminar.

Bentley Elected ACS Fellow

BioE chair recognized for research and service.

Science Gets Bentley and Payne's Perspective on Self-Assembly

BioE/IBBR professors invited to share views on new materials for biomedical applications.

BioE Capstone 2013: New Products Focus on Diagnostics, Physical Therapy and More

Students' inventions address needs ranging from home care to ICU.

Bentley Discusses Alternatives to Animal Testing in PRiSM

Lab-on-a-chip devices could reduce or eliminate need.

Maryland Exchange with Italian University Boosts Research on Artificial Cells

Bioengineering grad student part of international effort to use messages sent by synthetic cells to guide natural cell activity.

2012-2013 BioE Undergraduate Awards

Exceptional students recognized at annual ceremony.

Payne Honored with Guest Professorship

Wuhan University awards three-year appointment.

UMD and JHU Students Join Forces for Research Day

"Amplifying the Field" celebrates undergraduate contributions to biomedical research.

Rappaport Wins HHMI Fellowship

Award supports senior’s efforts to develop treatments for rare genetic disorders.

New Microfluidic Device Could Speed Drug Evaluation

Meyer wins Bioscience Day Poster division for work on device capable of separating, testing distinct areas of same biofilm.

Bentley Wins AIChE Division Award

Professor will deliver plenary talk at national meeting in October.

Gordonov Completes NSF Summer Research Fellowship in Singapore

Grad student one of 15 selected for East Asia and Pacific Summer Institute.

enGENEious Bentley Talks Quorum Sensing at Oxford

Professor invited to student- and postdoc-organized conference.

Fisher Promoted

Faculty member elevated to rank of full professor.

Muro Promoted

Faculty member becomes Associate Professor, receives tenure.

Capstone 2012: Innovations in Emergency Medicine, Diagnostic Tools, Physical Therapy, and More

BioE seniors present an array of new devices for improving health and safety.

Award Supports Development of Safer Batteries for Biomedical Devices

Sophomore Mian Khalid wins prestigious Howard Hughes Medical Institute fellowship for work with Kofinas Group.

2011-2012 BioE Undergraduate Awards

Exceptional students recognized by the Department, Clark School, and professional societies.

Bentley, Mansy to Explore Living/Artificial Cell Communication

International collaboration funded by new Maryland partnership with Trento, Italy.

Bacteria Programmed to Re-Create UMD Logo

Feat part of larger body of Clark School research into preventing infections.

Aranda-Espinoza, Hsieh Promoted

BioE faculty members promoted to Associate Professor, receive tenure.

Fight Bacteria With Bacteria

Alumnus creates bacterium that sacrifices itself to save you.

Inoue Joins BioE as Professor of the Practice

Canon U.S. Life Sciences senior fellow developing system for rapid diagnosis of disease.

"Bacterial Dirigibles" Emerge as Next-Generation Disease Fighters

Programmable bacteria cut out the middle-man, producing medicine in the body where needed.

Bentley, Payne Receive USM Regents' Awards for Nano-, Biodevice Work

Professors recognized for exemplary scholarship and research.

Bentley Named to Rabin Professorship

Professorship supports new and emerging fields in engineering.