Faculty Directory

Clyne, Alisa Morss

Clyne, Alisa Morss

Associate Chair, Diversity, Equity, and Inclusion
Fischell Fellow
ADVANCE Professor
Fischell Department of Bioengineering
Brain and Behavior Institute
Robert E. Fischell Institute for Biomedical Devices
4224 A. James Clark Hall

Ph.D., Medical and Mechanical Engineering, Massachusetts Institute of Technology 
M.S., Mechanical Engineering, University of Cincinnati

B.S., Mechanical Engineering, Stanford University 
Dr. Clyne is director of the Vascular Kinetics Laboratory, which unravels the complexity of vascular diseases ranging from the very common (atherosclerosis, Alzheimer's disease) to the very rare (Niemann Pick). She is particularly interested in how altered blood flow (e.g., during exercise or at an arterial bifurcation) and altered blood metabolites (e.g., high glucose in diabetes) contribute to disease in people from diverse backgrounds. The laboratory uses 3D in vitro systems, computational models, and animal and human studies to discover fundamental biological mechanisms, which then enable innovative vascular disease therapies.
Dr. Clyne is a fellow of the American Society of Mechanical Engineering  (ASME), Biomedical Engineering Society (BMES), American Heart Association (AHA), and the American Institute for Medical and Biological Engineering (AIMBE). She received the NSF CAREER award in 2008, an AHA National Scientist Development Grant in 2010, and the BMES-CMBE Rising Star award in 2011. Her research and educational innovations are funded by NSF, NIH, AHA, and the Department of Education. She is proud of receiving the Elizabeth Bingham mentoring award from the Association for Women in Science in recognition of her life-long efforts to promote diversity in science and engineering.

Dr. Clyne's Vascular Kinetics Laboratory conducts research at the interface of engineering, biochemistry, and vascular biology. In their prior work, the group largely focused on how an altered glucose environment (e.g., in diabetes) impaired endothelial cell response to shear stress and cyclic strain. Dr. Clyne and her lab have demonstrated that endothelial cells in high glucose do not respond appropriately to mechanical stimuli. Today, the group focuses primarily on the opposite question: how the mechanical environment affects endothelial cell glucose metabolism. They are integrating mechanobiology and metabolism, with the hope of using metabolic engineering to decrease the burden of cardiovascular disease and cancer. With new collaboration opportunities at the University of Maryland, Dr. Clyne and her lab group plan to extend their cell and animal work into human studies.

  • Laminar and disturbed flow effects on endothelial glucose metabolism
  • Computational models of endothelial glucose metabolism
  • Impaired endothelial mechanosensing in pulmonary arterial hypertension
  • Arterial stiffness in spinal cord injury
  • Perfusion effects on cancer metabolism
  • Vascular glucose transport in traumatic brain injury and Alzheimer’s disease
  • Pressure myography-on-a-chip
  • Energy Fields to Control Mitochondrial Metabolism

Agents of Positive Change: Highlighting Women Maryland Engineers

In celebration of Women's History Month, we highlight some of the important contributions of women engineers within our campus community.

Two BIOE Students Win Outstanding Graduate Assistant Awards

BIOE's Ann Ramirez and Callie Weber received the 2023–24 Outstanding Graduate Assistant Awards.

Maisel & Mueller Win Provost's Do Good Innovator Awards

Assistant Professors Kathrina Maisel and Jenna Mueller are selected for the Do Good Innovator Awards.

Fischell Institute, BIOE Train Researchers To Be Better Mentors Through CIMER

CIMER’s training utilizes the Entering Mentoring curricula, an evidence-based, interactive approach designed to help mentors develop skills for engaging in productive, culturally responsive, research mentoring relationships—relationships that optimize the success of both mentors and mentees.

UMD Researchers to Lead NIH-funded Program Supporting Underrepresented Students

The MARC award will support an educational program for traditionally underrepresented students in STEM.

24 Teams Present at BIOE Capstone Competition Including First BCE Students

On May 8, 2023, 24 teams presented novel designs at the BIOE Capstone Design Competition.

Five BIOE Students & Alumni Named NSF Graduate Research Fellows

The NSF Graduate Research Fellowship Program (GRFP) was established to ensure the vitality and diversity of the scientific and engineering workforce of the United States.

Fischell Fellow Spotlight: Alisa Clyne

Clyne's area of expertise is cardiovascular mechanobiology and metabolism.

Recent Bioengineering Graduate Awarded National Mitchell Scholarship

Neelesh Mupparapu (B.S. bioengineering '22) named one of 12 winners to pursue graduate study in Ireland

Weber, Stewart Named Fischell Fellows

BIOE names two recipients of prestigious department award

$7.9 Million in NIH Awards Propel UMD Aging Research

New multidisciplinary collaborations take on challenges like Alzheimer’s disease prevention.

BIOE Announces Spring 2022 Instructional Impact Awards

The Fischell Department of Bioengineering honored three educators, nominated by students and peers.

BIOE Capstone Competition Highlights 24 Novel Projects

The Bioengineering Senior Capstone Design competition returned to in-person on Monday, May 2.

Celebrating 14 Participants of 2021 BIOE REU Program

The BIOE REU program promotes collaboration between UMD and the FDA, making it unlike any other in the country

Maisel to Investigate Little-Known Organ in the Body

Dr. Katharina Maisel was awarded a $1.8 million NIH NIGMS grant to study the interstitium and lymphatics.

Clyne, Ma, Stroka Promoted

The three BIOE faculty are promoted to Professor, Senior Lecturer, and Associate Professor, respectively.

BIOE Capstone Projects Focus on Medical Devices, AI, and More

BIOE seniors present 23 novel Capstone projects live via Gatherly.

Maryland Graduate Engineering Ranked #10 Public in the Nation

From extreme batteries to windows made from wood, Clark School’s trendsetting work ranks it among the country’s Top 10 public engineering schools for the 3rd consecutive year.

One Size Does Not Fit All

To advance inclusive medical therapies and diversity in fundamental science, one Maryland engineer leads by example.

Clyne Named BIOE Associate Chair, Diversity, Equity & Inclusion

Role will support efforts to enhance diversity within the department and in the STEM fields at large.

BIOE Capstone Class Virtually Presents 24 Novel Projects

BIOE seniors present Capstone projects and celebrate winners virtually.

Clyne, Jewell Inducted into AIMBE College of Fellows

BIOE faculty awarded one of the highest professional distinctions accorded to a medical/biological engineer.

Clyne, Maisel to Join BIOE Faculty in 2019

Associate, assistant professors bring expertise in endothelial cell biology, mucosal drug delivery.

  • American Heart Association
  • American Institute for Medical and Biological Engineering
  • American Society of Mechanical Engineers