Faculty Directory

At the Amplified Molecular Sensors Lab, we aim to improve the speed of diagnostics. We design approaches that reduce or eliminate instrumentation, that are rapid, and - importantly - that are easy to use. To innovate, our lab emphasizes problem-solving over dogma, we think "translation" from day 1, and we consider the user perspective as the first step in our design.

At the Amplified Molecular Sensors Lab, we aim to improve the speed of diagnostics. We design approaches that reduce or eliminate instrumentation, that are rapid, and - importantly - that are easy to use. To innovate, our lab emphasizes problem-solving over dogma, we think "translation" from day 1, and we consider the user perspective as the first step in our design.

BIOE457: Biomedical Instrumentation

BIOE431: Fundamentals of Biosensing Techniques, Instrumentation, and Applications

• Alie M. Bogusch, Evan H. Benke, Jordan T. Ruit, Abraham A. Akinladenu, David J. Boegner, and Ian M. White, Automated enrichment of DNA biomarkers from large-volume samples: detection of B. burgdorferi cell free DNA in urine, Analytical Chemistry, 98, 3951–3958, 2026. DOI:10.1021/acs.analchem.5c06280.

• Rachel L. Warren, John R. Rzasa, Zehra F. Syeda, Alexander R. Pueschel, and Ian M. White, Portable histone assay technology (PHAST) for the sample-to-answer detection of circulating histones in whole blood, Sensors and Actuators B: Chemical, 447, 138848, 2026. DOI:10.1016/j.snb.2025.138848.

• Miso Na, David J. Boegner, Micaela L. Everitt, and Ian M. White, Thermally Responsive Alkane Partitions and a Magnetofluidic Assay for Point-of-Sample Detection of Viruses in Wastewater, Biosensors, 15, 276, 2025. DOI:10.3390/bios15050276

• Evan H. Benke, David J. Boegner, Alejandra M. Bogusch, and Ian M. White, Sample-to-answer detection of miRNA from whole blood using thermally responsive alkane partitions, Biosensors and Bioelectronics, 271, 117052, 2025. DOI:10.1016/j.bios.2024.117052

• David J. Boegner, John R. Rzasa, Evan H. Benke, and Ian M. White, Saliva-STAT: Sample-to-answer saliva test for COVID-19, Sensors and Actuators B: Chemical, 136510, 2024. DOI:10.1016/j.snb.2024.136510

• David J. Boegner, Miso Na, Anthony D. Harris, Robert H. Christenson, Colleen M. Damcott, Brent King, LaToya Stubbs, Peter Rock, and Ian M. White, Sample-to-answer detection of SARS-CoV-2 viremia using thermally responsive alkane partitions, Analytical Chemistry, 96, 12049–12056, 2024. DOI:10.1021/acs.analchem.4c02105.

• Micaela L. Everitt, David J. Boegner, and Ian M. White, Sample-to-Answer Immuno-Magnetic Assay Using Thermally Responsive Alkane Partitions, Biosensors, 12, 1030, 2022. DOI:10.3390/bios12111030.

• David J. Boegner, Micaela L. Everitt, and Ian M. White, Thermally Responsive Alkane Partitions for Assay Automation, ACS Applied Materials and Interfaces, 14, 8865–8875, 2022. DOI:10.1021/acsami.2c00493.

• Shannon H. Hilton and Ian M. White, Advances in the analysis of single extracellular vesicles: a critical review, Sensors and Actuators Reports, 100052, 2021. DOI:10.1016/j.snr.2021.100052.

• Miceala L. Everitt, David Boegner, Konstantin Birukov, and Ian M. White, Sample-to-Answer Diagnostic System for the Detection of Circulating Histones in Whole Blood, ACS Sensors, 6, 3006-3012, 2021. DOI:10.1021/acssensors.1c00886.

• Miceala L. Everitt, Alana Tillery, Martha G. David, Nikita Singh, Aviva Borison, and Ian M. White, A critical review of point-of-care diagnostic technologies to combat viral pandemics, Analytica Chimica Acta, 1146, 184-189, 2020. DOI:10.1016/j.aca.2020.10.009.

• Shannon H. Hilton, Connor Hall, Hieu T. Nguyen, Micaela L. Everitt, Philip DeShong, and Ian M. White, Phenotypically distinguishing ESBL-producing pathogens using paper-based surface enhanced Raman sensors, Analytica Chimica Acta, 1127, 207-216, 2020. DOI:10.1016/j.aca.2020.06.068.

• Alessandra C. Zimmerman, Ian M. White, and Jason D. Kahn, "Nucleic acid-cleaving catalytic DNA for sensing and therapeutics, Talanta, in press, 2020.

• Hieu T. Nguyen, Shweta Ganapati, David Watts, Imaly A. Nanayakkara, Philip DeShong, Ian M. White, A new trimodal phenotypic reporter of extended-spectrum beta-lactamase activity, ACS Infectious Disease, in press, 2019. DOI:10.1021/acsinfecdis.9b00138.

• Imaly A. Nanayakkara and Ian M. White, Demonstration of a quantitative triplex LAMP assay with an improved probe-based readout for the detection of MRSA, Analyst, 144, 3878 - 3885, 2019. DOI:10.1039/C9AN00671K.

• John P. Goertz, Kerry DeMella, Benjamin Thompson, Ian M. White, and Srinivasa Raghavan, Responsive capsules that enable hermetic encapsulation of contents and their thermally triggered burst-release, Materials Horizons, in press, 2019. DOI:10.1039/c9mh00309f.

• Stephen M. Restaino and Ian M. White, A critical review of flexible and porous SERS sensors for analytical chemistry at the point-of-sample, Analytica Chimica Acta, 1060, 17-29, 2019, DOI:10.1016/j.aca.2018.11.057

• John P. Goertz, Kenya Colvin, Andrew Lippe, John Daristotle, Peter Kofinas, and Ian M. White, Multi-Stage Chemical Heating for Instrument-Free Biosensing, ACS Applied Materials and Interfaces, 10, 33043–33048, 2018. DOI:10.1021/acsami.8b11611

• John P. Goertz and Ian M. White, Phase-change partitions for thermal automation of multi-step reactions, Analytical Chemistry, 90, 3708–3713, 2018. DOI:10.1021/acs.analchem.7b05400.

• Stephen M. Restaino and Ian M. White, Real-time multiplexed PCR using surface enhanced Raman spectroscopy in a thermoplastic chip, Lab on a Chip, 18, 832-839, 2018. DOI:10.1039/C7LC01227F.

• John P. Goertz and Ian M. White, Peroxidyme-Amplified Radical Chain Reaction (PARCR): Nested Photochemical and Biochemical Positive Feedback, Angewandte Chemie, 56, 13411–13415, 2017. DOI:10.1002/anie.201706163.

• Imaly A. Nanayakkara, Weidong Cao, and Ian M. White, Simplifying nucleic acid amplification from whole blood with direct PCR on chitosan microparticles, Analytical Chemistry, 89, 3773–3779, 2017. DOI:10.1021/acs.analchem.7b00274.

• Adam G. Berger, Stephen M. Restaino, and Ian M. White, Vertical-flow paper SERS system for therapeutic drug monitoring of flucytosine in serum, Analytica Chimica Acta, 949C, 59-66, 2017. DOI:10.1016/j.aca.2016.10.035

• Kunal R. Pandit, Imaly A. Nanayakkara, Weidong Cao, Srinivasa R. Raghavan, and Ian M. White, Capture and direct amplification of DNA on chitosan microparticles in a single PCR-optimal solution, Analytical Chemistry, 87, 11022-11029, 2015. DOI:10.1021/acs.analchem.5b03006

• Kunal R. Pandit, Paul E. Rueger, Richard V. Calabrese, Srinivasa R. Raghavan, and Ian M. White, Assessment of surfactants for efficient droplet PCR in mineral oil using the pendant drop technique, Journal of Colloids and Surfaces B: Biointerfaces, 126, 489-495, 2015. DOI:10.1016/j.colsurfb.2015.01.001

• Jeffrey M. Burke, Kunal Pandit, John P. Goertz, and Ian M. White, Fabrication of rigid microstructures with thiol-ene-based soft lithography for continuous-flow cell lysis, Biomicrofluidics, 8, 056503, 2014. DOI:10.1063/1.4897135.

• Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Multiplex detection of DNA targets using polymerase chain reaction (PCR) and paper surface enhanced Raman spectroscopy (SERS) chromatography, Applied Spectroscopy, 68, 909-915, 2014. DOI:10.1366/14-07451.

• Jeffrey M. Burke, Rebecca E. Zubajlo, Elisabeth Smela, and Ian M. White, High-throughput particle separation and concentration using spiral inertial filtration, Biomicrofluidics, 8, 024105 2014. DOI:10.1063/1.4870399.

• Jordan F. Betz, Wei W. Yu, Yi Cheng, Ian M. White, and Gary W. Rubloff, Simple SERS substrates: powerful, portable, and full of potential, Physical Chemistry Chemical Physics, 16, 2224-2239, 2014. DOI:10.1039/C3CP53560F.

• Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Inkjet-printed fluidic paper devices for chemical and biological analytics using surface enhanced Raman spectroscopy, Journal of Selected Topics in Quantum Electronics, 20, 7300510, 2014. DOI:10.1109/JSTQE.2013.2286076.

• Soroush H. Yazdi, Kristen L. Giles, and Ian M. White, Multiplexed detection of DNA sequences using a competitive displacement assay in an microfluidic SERRS-based device, Analytical Chemistry, 85, 10605-10611, 2013. DOI:10.1021/ac402744z.

• Eric P. Hoppmann, Wei W. Yu, and Ian M. White, Highly sensitive and flexible inkjet printed SERS sensors on paper, Methods, 63, 219-224, 2013. DOI:10.1016/j.ymeth.2013.07.010.

• Wei W. Yu and Ian M. White, Chromatographic separation and detection of target analytes from complex samples using inkjet printed SERS substrates, Analyst, 138, 3679-3686 2013. DOI:10.1039/C3AN00673E.

• Katayoon Saadin, Jeffrey M. Burke, Neerav P. Patel, Rebecca E. Zubajlo, and Ian M. White, Enrichment of tumor-initiating breast cancer cells within a mammosphere-culture microdevice, Biomedical Microdevices, 15, 645-655, 2013. DOI:10.1007/s10544-013-9755-y.

• Wei W. Yu and Ian M. White, Inkjet-Printed Paper-Based SERS Dipsticks and Swabs for Trace Chemical Detection, Analyst, 138, 1020-1025, 2013. DOI:10.1039/C2AN36116G. (outside front cover)

• Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.

• Soroush H. Yazdi and Ian M. White, Multiplexed detection of aquaculture fungicides using a pump-free optofluidic SERS microsystem, Analyst, 138, 100-103, 2013. DOI:10.1039/C2AN36232E.

• Soroush H. Yazdi and Ian M. White, An Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Chemical Contaminants, Analytical Chemistry, 84, 7992-7998, 2012. DOI:10.1021/ac301747b.

• Katayoon Saadin and Ian M. White, Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications, Expert Reviews of Molecular Diagnostics, 13, 49-60, 2013. DOI:10.1586/erm.12.117.

• Ian M. White, Soroush H. Yazdi, and Wei W. Yu, Optofluidic SERS: synergizing photonics and microfluidics for chemical and biological analysis, Microfluidics and Nanofluidics, 12, 205-216, 2012. DOI:10.1007/s10404-012-0962-2

• Wei W. Yu and Ian M. White, A simple filter-based approach to surface enhanced Raman spectroscopy for trace chemical detection, Analyst, 137, 168-173, 2012. DOI:10.1039/C2AN15947C.

• Soroush H. Yazdi and Ian M. White, A nanoporous optofluidic microsystem for highly sensitive and repeatable SERS detection, Biomicrofluidics, 6, 014105, 2012. DOI:10.1063/1.3677369. (selected for publication in the Virtual Journal of Nanoscale Science and Technology and the Virtual Journal of Biological Physics Research)

• Xudong Fan and Ian M. White, Optofluidic microsystems for chemical and biological analysis, Nature Photonics, 5, 591-597, 2011. DOI:10.1038/nphoton.2011.206.

• I-Jane Chen and Ian M. White, High-sensitivity electrochemical enzyme-linked assay on a microfluidic interdigitated microelectrode, Biosensors and Bioelectronics, 26, 4375-4381, 2011. DOI:10.1016/j.bios.2011.04.044.

• Wei W. Yu and Ian M. White, Inkjet Printed Surface Enhanced Raman Spectroscopy Array on Cellulose Paper, Analytical Chemistry 82, 9626-9630, 2010. DOI:10.1021/ac102475k.

• Jikun Liu, Ian M. White, and Don L. DeVoe, Nanoparticle-Functionalized Porous Polymer Monolith Detection Elements for Surface-Enhanced Raman Scattering, Analytical Chemistry, 83, 2119-2124, 2011. DOI:10.1021/ac102932d.